TY - JOUR
T1 - Fecal Steroid 21‐Dehydroxylase, a Potential Marker for Colorectal Cancer
AU - Bokkenheuser, Victor D.
AU - Winter, Jeanette
AU - Mosenthal, Anne C.
AU - Mosbach, Erwin H.
AU - McSherry, Charles K.
AU - Ayengar, Narayan K.N.
AU - Andrews, A. W.
AU - Lebherz, William B.
AU - Pienta, Roman J.
AU - Wallenstein, Sylvan
PY - 1983/8
Y1 - 1983/8
N2 - Eubacterium lentum and phenotypically similar organisms synthesize a steroid 21‐dehydroxylase which converts biliary tetrahydrodeoxycorticosterone to pregnanolone. Tetrahydrodeoxycorticosterone, in contrast to pregnanolone, is carcinogenic for hamster embryonic cells (HECT test). In patients with recently diagnosed, untreated sigmoidal or rectal cancer the fecal concentration of 21‐dehydroxylating organisms is reduced by more than 99% as compared with age‐matched controls. I he lack of fecal 21‐dehydroxylating organisms, therefore, is a potential marker for the disorder. The role of steroid 21‐dehydroxylase in the pathogenesis of colorectal cancer is unknown.
AB - Eubacterium lentum and phenotypically similar organisms synthesize a steroid 21‐dehydroxylase which converts biliary tetrahydrodeoxycorticosterone to pregnanolone. Tetrahydrodeoxycorticosterone, in contrast to pregnanolone, is carcinogenic for hamster embryonic cells (HECT test). In patients with recently diagnosed, untreated sigmoidal or rectal cancer the fecal concentration of 21‐dehydroxylating organisms is reduced by more than 99% as compared with age‐matched controls. I he lack of fecal 21‐dehydroxylating organisms, therefore, is a potential marker for the disorder. The role of steroid 21‐dehydroxylase in the pathogenesis of colorectal cancer is unknown.
UR - https://www.scopus.com/pages/publications/0020507508
U2 - 10.1111/j.1572-0241.1983.tb01905.x
DO - 10.1111/j.1572-0241.1983.tb01905.x
M3 - Article
C2 - 6603789
AN - SCOPUS:0020507508
SN - 0002-9270
VL - 78
SP - 469
EP - 475
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 8
ER -