@article{86f15921f4304a82b6dc933b8c333594,
title = "Fecal IgA Levels Are Determined by Strain-Level Differences in Bacteroides ovatus and Are Modifiable by Gut Microbiota Manipulation",
abstract = "Yang et al. identify that different Bacteroides ovatus strains induce either high or low baseline fecal IgA in mice. Cocktails of IgAhigh B. ovatus strains convert mice from low-IgA to high-IgA producers. This demonstrates a role of microbial strains in immune variation and a microbiota-based immune modulation strategy.",
keywords = "Bacteroides ovatus, gut microbiota, immune modulation, immunoglobulin A, strains",
author = "Chao Yang and Ilaria Mogno and Contijoch, {Eduardo J.} and Borgerding, {Joshua N.} and Varun Aggarwala and Zhihua Li and Sophia Siu and Grasset, {Emilie K.} and Helmus, {Drew S.} and Dubinsky, {Marla C.} and Saurabh Mehandru and Andrea Cerutti and Faith, {Jeremiah J.}",
note = "Funding Information: We are grateful to Cinkia Fermin, Edwin Vazquez, and Grant Escano for the husbandry of gnotobiotic mice and Drs. Anuk A. Das, Dirk D. Gevers, Charlotte Cunningham-Rundles, Brian Brown, and Thomas Moran for helpful discussions and comments. This work was supported in part by the staff and resources of the Gnotobiotic Mouse Core Facility, the Microbiome Translational Center, the Flow Cytometry Core Facility, the Microscopy CoRE, and the Scientific Computing Division in Icahn School of Medicine at Mount Sinai. This work was supported by National Institutes of Health (NIH), United States grants (NIGMS GM108505, NCCIH AT008661, NIDDK DK112978) and Janssen Human Microbiome Institute (to J.J.F.) and NIH DK112679 (to E.J.C.). C.Y. and J.J.F conceived the study and designed the experiments; C.Y. I.M. E.J.C. J.N.B. V.A. S.S. E.K.G. D.S.H. M.C.D. and J.J.F. collected samples and conducted the experiments; I.M. and Z.L. provided bacterial isolates; C.Y. S.M. A.C. and J.J.F. analyzed data; C.Y. and J.J.F. prepared the manuscript. All authors read and approved the final manuscript. J.J.F. serves as a consultant for Janssen Research & Development LLC. All remaining authors declare no conflict of interests. Funding Information: We are grateful to Cinkia Fermin, Edwin Vazquez, and Grant Escano for the husbandry of gnotobiotic mice and Drs. Anuk A. Das, Dirk D. Gevers, Charlotte Cunningham-Rundles, Brian Brown, and Thomas Moran for helpful discussions and comments. This work was supported in part by the staff and resources of the Gnotobiotic Mouse Core Facility, the Microbiome Translational Center, the Flow Cytometry Core Facility, the Microscopy CoRE, and the Scientific Computing Division in Icahn School of Medicine at Mount Sinai. This work was supported by National Institutes of Health (NIH), United States grants ( NIGMS GM108505 , NCCIH AT008661 , NIDDK DK112978 ) and Janssen Human Microbiome Institute (to J.J.F.) and NIH DK112679 (to E.J.C.). Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = mar,
day = "11",
doi = "10.1016/j.chom.2020.01.016",
language = "English",
volume = "27",
pages = "467--475.e6",
journal = "Cell Host and Microbe",
issn = "1931-3128",
publisher = "Cell Press",
number = "3",
}