TY - JOUR
T1 - Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes
T2 - results from the IMPACC study
AU - IMPACC Network
AU - IMPACC Steering Committee
AU - Clinical Data Coordinating Center (CDCC)
AU - IMPACC Data Analysis Group
AU - IMPACC Site Investigators
AU - IMPACC Core Laboratory
AU - IMPACC Clinical Study Team
AU - Ozonoff, Al
AU - Jayavelu, Naresh Doni
AU - Liu, Shanshan
AU - Melamed, Esther
AU - Milliren, Carly E.
AU - Qi, Jingjing
AU - Geng, Linda N.
AU - McComsey, Grace A.
AU - Cairns, Charles B.
AU - Baden, Lindsey R.
AU - Schaenman, Joanna
AU - Shaw, Albert C.
AU - Samaha, Hady
AU - Seyfert-Margolis, Vicki
AU - Krammer, Florian
AU - Rosen, Lindsey B.
AU - Steen, Hanno
AU - Syphurs, Caitlin
AU - Dandekar, Ravi
AU - Shannon, Casey P.
AU - Sekaly, Rafick P.
AU - Ehrlich, Lauren I.R.
AU - Corry, David B.
AU - Kheradmand, Farrah
AU - Atkinson, Mark A.
AU - Brakenridge, Scott C.
AU - Agudelo Higuita, Nelson I.
AU - Metcalf, Jordan P.
AU - Hough, Catherine L.
AU - Messer, William B.
AU - Pulendran, Bali
AU - Nadeau, Kari C.
AU - Davis, Mark M.
AU - Sesma, Ana Fernandez
AU - Simon, Viviana
AU - van Bakel, Harm
AU - Kim-Schulze, Seunghee
AU - Lee, Brian
AU - Kojic, Erna
AU - Rahman, Adeeb
AU - Stadlbauer, Daniel
AU - Gonzalez-Reiche, Ana Silvia
AU - Xie, Hui
AU - Kelly, Geoffrey
AU - Patel, Manishkumar
AU - Nie, Kai
AU - Saksena, Miti
AU - Altman, Deena
AU - Mulder, Lubbertus C.F.
AU - Kleiner, Giulio
N1 - Publisher Copyright:
© 2024, The Author(s).
PY - 2024/1
Y1 - 2024/1
N2 - Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated with female sex and distinctive comorbidities. During the acute phase of disease, a higher respiratory SARS-CoV-2 viral burden and lower Receptor Binding Domain and Spike antibody titers were associated with both the physical predominant and the multidomain deficit clusters. A lower frequency of circulating B lymphocytes by mass cytometry (CyTOF) was observed in the multidomain deficit cluster. Circulating fibroblast growth factor 21 (FGF21) was significantly elevated in the mental/cognitive predominant and the multidomain clusters. Future efforts to link PASC to acute anti-viral host responses may help to better target treatment and prevention of PASC.
AB - Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated with female sex and distinctive comorbidities. During the acute phase of disease, a higher respiratory SARS-CoV-2 viral burden and lower Receptor Binding Domain and Spike antibody titers were associated with both the physical predominant and the multidomain deficit clusters. A lower frequency of circulating B lymphocytes by mass cytometry (CyTOF) was observed in the multidomain deficit cluster. Circulating fibroblast growth factor 21 (FGF21) was significantly elevated in the mental/cognitive predominant and the multidomain clusters. Future efforts to link PASC to acute anti-viral host responses may help to better target treatment and prevention of PASC.
UR - http://www.scopus.com/inward/record.url?scp=85181510888&partnerID=8YFLogxK
U2 - 10.1038/s41467-023-44090-5
DO - 10.1038/s41467-023-44090-5
M3 - Article
C2 - 38172101
AN - SCOPUS:85181510888
SN - 2041-1723
VL - 15
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 216
ER -