@inproceedings{9fc2fb794ec840d699b7fe3c270a38bc,
title = "Feasibility of a chronic, minimally invasive endovascular neural interface",
abstract = "Development of a neural interface that can be implanted without risky, open brain surgery will increase the safety and viability of chronic neural recording arrays. We have developed a minimally invasive surgical procedure and an endovascular electrode-array that can be delivered to overlie the cortex through blood vessels. Here, we describe feasibility of the endovascular interface through electrode viability, recording potential and safety. Electrochemical impedance spectroscopy demonstrated that electrode impedance was stable over 91 days and low frequency phase could be used to infer electrode incorporation into the vessel wall. Baseline neural recording were used to identify the maximum bandwidth of the neural interface, which remained stable around 193 Hz for six months. Cross-sectional areas of the implanted vessels were non-destructively measured using the Australian Synchrotron. There was no case of occlusion observed in any of the implanted animals. This work demonstrates the feasibility of an endovascular neural interface to safely and efficaciously record neural information over a chronic time course.",
author = "Opie, {Nicholas L.} and Rind, {Gil S.} and John, {Sam E.} and Ronayne, {Stephen M.} and Grayden, {David B.} and Burkitt, {Anthony N.} and May, {Clive N.} and O'Brien, {Terence J.} and Oxley, {Thomas J.}",
note = "Publisher Copyright: {\textcopyright} 2016 IEEE.; 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 ; Conference date: 16-08-2016 Through 20-08-2016",
year = "2016",
month = oct,
day = "13",
doi = "10.1109/EMBC.2016.7591716",
language = "English",
series = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "4455--4458",
booktitle = "2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016",
address = "United States",
}