Feasibility and Safety of Substituting Lung Ultrasonography for Chest Radiography When Diagnosing Pneumonia in Children: A Randomized Controlled Trial

Brittany Pardue Jones, Ee Tein Tay, Inna Elikashvili, Jennifer E. Sanders, Audrey Z. Paul, Bret P. Nelson, Louis A. Spina, James W. Tsung

Research output: Contribution to journalArticlepeer-review

148 Scopus citations

Abstract

Background Chest radiography (CXR) is the test of choice for diagnosing pneumonia. Lung ultrasonography (LUS) has been shown to be accurate for diagnosing pneumonia in children and may be an alternative to CXR. Our objective was to determine the feasibility and safety of substituting LUS for CXR when evaluating children suspected of having pneumonia. Methods We conducted a randomized control trial comparing LUS with CXR in 191 children from birth to 21 years of age suspected of having pneumonia in an ED. Patients in the investigational arm underwent LUS. If there was clinical uncertainty after ultrasonography, physicians had the option to perform CXR. Patients in the control arm underwent sequential imaging with CXR followed by LUS. The primary outcome was the rate of CXR reduction; secondary outcomes were missed pneumonia, subsequent unscheduled health-care visits, and adverse events between the investigational and control arms. Results There was a 38.8% reduction (95% CI, 30.0%-48.9%) in CXR among investigational subjects compared with no reduction (95% CI, 0.0%-3.6%) in the control group. Novice and experienced physician-sonologists achieved 30.0% and 60.6% reduction in CXR use, respectively. There were no cases of missed pneumonia among all study participants (investigational arm, 0.0%: 95% CI, 0.0%-2.9%; control arm, 0.0%: 95% CI, 0.0%-3.0%), or differences in adverse events, or subsequent unscheduled health-care visits between arms. Conclusions It may be feasible and safe to substitute LUS for CXR when evaluating children suspected of having pneumonia with no missed cases of pneumonia or increase in rates of adverse events. Trial Registry ClinicalTrials.gov; No.: NCT01654887; URL: www.clinicaltrials.gov

Original languageEnglish
Pages (from-to)131-138
Number of pages8
JournalChest
Volume150
Issue number1
DOIs
StatePublished - 1 Jul 2016

Keywords

  • chest radiography
  • emergency medicine
  • lung ultrasound
  • pediatrics
  • pneumonia

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