Feasibility and safety of stereoelectroencephalography in young children

Carrie R. Muh, Jessica R. Dorilio, Cameron P. Beaudreault, Patricia E. McGoldrick, Jared M. Pisapia, Steven M. Wolf

Research output: Contribution to journalShort surveypeer-review

1 Scopus citations

Abstract

Purpose: Stereoelectroencephalography (SEEG) is a diagnostic surgery that implants electrodes to identify areas of epileptic onset in patients with drug-resistant epilepsy (DRE). SEEG is effective in identifying the epileptic zone; however, placement of electrodes in very young children has been considered contraindicated due to skull thinness. The goal of this study was to evaluate if SEEG is safe and accurate in young children with thin skulls. Methods: Four children under the age of two years old with DRE underwent SEEG to locate the region of seizure onset. Presurgical planning and placement of electrodes were performed using ROSA One Brain. Preoperative electrode plans were merged with postoperative CT scans to determine accuracy. Euclidean distance between the planned and actual trajectories was calculated using a 3D coordinate system at both the entry and target points for each electrode. Results: Sixty-three electrodes were placed among four patients. Mean skull thickness at electrode entry sites was 2.34 mm. The mean difference between the planned and actual entry points was 1.12 mm, and the mean difference between the planned and actual target points was 1.73 mm. No significant correlation was observed between planned and actual target points and skull thickness (Pearson R = − 0.170). No perioperative or postoperative complications were observed. Conclusions: This study demonstrates that SEEG can be safe and accurate in children under two years of age despite thin skulls. SEEG should be considered for young children with DRE, and age and skull thickness are not definite contraindications to the surgery.

Original languageEnglish
Pages (from-to)1331-1337
Number of pages7
JournalChild's Nervous System
Volume40
Issue number5
DOIs
StatePublished - May 2024
Externally publishedYes

Keywords

  • Depth electrodes
  • Epilepsy surgery
  • Intracranial EEG
  • Pediatric
  • SEEG
  • Toddler

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