Fc receptor-mediated signal transduction

Ching Tai Lin, Zhenhai Shen, Peter Boros, Jay C. Unkeless

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Receptors for the Fc domain of IgG (FcγRs) on leukocytes mediate a pleiotropic response following cross-linking by immune complexes. Signaling events following cross-linking of B and T cell antigen receptors, FcRs, and FcγRs share common elements. In each, signaling is initiated by receptor cross-linking by antigen or immune complexes and results in the activation of src family kinases and ZAP-70-related tyrosine kinases, which associate with members of the receptor complex. Subsequent events include phosphorylation on tyrosine of multiple cellular substrates including phospholipase Cγ1 and PI3-kinase. The [Ca2+]i flux is an event secondary to phospholipase Cγ1 activation. Protein tyrosine kinase inhibitors block both early events such as [Ca2+]i flux and the later effects of cytokine release and cellular proliferation.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalJournal of Clinical Immunology
Volume14
Issue number1
DOIs
StatePublished - Jan 1994

Keywords

  • Fc receptor
  • SH2
  • SH3
  • glycan phosphatidylinositol
  • protein tyrosine kinase
  • signal transduction

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