Abstract
Receptors for the Fc domain of IgG (FcγRs) on leukocytes mediate a pleiotropic response following cross-linking by immune complexes. Signaling events following cross-linking of B and T cell antigen receptors, Fc∈Rs, and FcγRs share common elements. In each, signaling is initiated by receptor cross-linking by antigen or immune complexes and results in the activation of src family kinases and ZAP-70-related tyrosine kinases, which associate with members of the receptor complex. Subsequent events include phosphorylation on tyrosine of multiple cellular substrates including phospholipase Cγ1 and PI3-kinase. The [Ca2+]i flux is an event secondary to phospholipase Cγ1 activation. Protein tyrosine kinase inhibitors block both early events such as [Ca2+]i flux and the later effects of cytokine release and cellular proliferation.
Original language | English |
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Pages (from-to) | 1-13 |
Number of pages | 13 |
Journal | Journal of Clinical Immunology |
Volume | 14 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1994 |
Keywords
- Fc receptor
- SH2
- SH3
- glycan phosphatidylinositol
- protein tyrosine kinase
- signal transduction