The authors characterize the possible role of circulating autoantibodies specific for Fc gamma receptors in autoimmune diseases. Dysfunction of Fc gamma receptors, resulting in prolonged clearance of immune complexes, has been observed in both systemic and organ specific autoimmune disorders. Although the mechanism of the defective Fc gamma receptor function is not clearly understood, some findings suggest that Fc gamma receptor specific autoantibodies may have significant part in these processes. The authors found high titers of anti-Fc gamma receptor autoantibodies in the sera of several mouse strains prone to autoimmune diseases, and then extended these observations to human autoimmune diseases. They analized the specificity and functional effects of these antibodies. The authors hypothesize, that Fc gamma receptor specific autoantibodies may play a role in the pathology of autoimmune diseases by stimulating Fc gamma-receptor-bearing cells to release oxygen intermediates, different lysosomal hydrolases and cytokines or by blocking the phagocytosis of immune complexes.
|Translated title of the contribution
|The role of Fc gamma R specific autoantibodies in autoimmune diseases. Review of the literature and authors' own research
|Number of pages
|Published - 17 Mar 1996