Fatal disseminated adenovirus 11 pneumonia in an agammaglobulinemic patient

Frederick P. Siegal, Steven H. Dikman, Ricardo B. Arayata, Edward J. Bottone

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Adenovirus type 11, an organism not previously associated with pneumonia, caused the death of a patient with infantile x-linked agammaglobulinemia who had normal cell-mediated immunity. Despite long-standing, regular therapy with immune globulin, his serum lacked neutralizing antibody to the virus. This case confronts the conventional view that viral infections are primarily resisted by cellular immune reactions and reemphasizes the importance of antibody in the host defense against adenoviruses. It further demonstrates the continued vulnerability of such patients to certain pathogens in the presence of presumably adequate standard-dose passive immunization.

Original languageEnglish
Pages (from-to)1062-1067
Number of pages6
JournalAmerican Journal of Medicine
Issue number6
StatePublished - Dec 1981


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