TY - JOUR
T1 - Fatal disseminated adenovirus 11 pneumonia in an agammaglobulinemic patient
AU - Siegal, Frederick P.
AU - Dikman, Steven H.
AU - Arayata, Ricardo B.
AU - Bottone, Edward J.
PY - 1981/12
Y1 - 1981/12
N2 - Adenovirus type 11, an organism not previously associated with pneumonia, caused the death of a patient with infantile x-linked agammaglobulinemia who had normal cell-mediated immunity. Despite long-standing, regular therapy with immune globulin, his serum lacked neutralizing antibody to the virus. This case confronts the conventional view that viral infections are primarily resisted by cellular immune reactions and reemphasizes the importance of antibody in the host defense against adenoviruses. It further demonstrates the continued vulnerability of such patients to certain pathogens in the presence of presumably adequate standard-dose passive immunization.
AB - Adenovirus type 11, an organism not previously associated with pneumonia, caused the death of a patient with infantile x-linked agammaglobulinemia who had normal cell-mediated immunity. Despite long-standing, regular therapy with immune globulin, his serum lacked neutralizing antibody to the virus. This case confronts the conventional view that viral infections are primarily resisted by cellular immune reactions and reemphasizes the importance of antibody in the host defense against adenoviruses. It further demonstrates the continued vulnerability of such patients to certain pathogens in the presence of presumably adequate standard-dose passive immunization.
UR - http://www.scopus.com/inward/record.url?scp=0019785601&partnerID=8YFLogxK
U2 - 10.1016/0002-9343(81)90343-0
DO - 10.1016/0002-9343(81)90343-0
M3 - Article
C2 - 6274190
AN - SCOPUS:0019785601
SN - 0002-9343
VL - 71
SP - 1062
EP - 1067
JO - American Journal of Medicine
JF - American Journal of Medicine
IS - 6
ER -