Fatal complications after myelography with meglumine diatrizoate

M. J. Hilz; W. Huk; B. Schellmann; F. Sörgel; K. F. Druschky

doi:10.1007/BF00593948

Fatal complications after myelography with meglumine diatrizoate

M. J. Hilz, W. Huk, B. Schellmann, F. Sörgel, K. F. Druschky

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25 Scopus citations

Abstract

A case of inadvertent intrathecal injection of diatrizoate meglumine is presented. After myelography with 10 ml i.e. 6.5 g Angiografin, a 76-year-old man rapidly developed myoclonus, drowsiness and excessive metabolic acidosis. He died only a few hours later. Postmortem showed non-specific brain edema. RP-HPL-Chromatography confirmed high concentration of the contrast medium in CSF (6 mg/ml) which must have induced refractory central nervous dysregulation. The lethal effects of the misapplication of this agent on the nervous system are discussed.

Original language	English
Pages (from-to)	70-73
Number of pages	4
Journal	Neuroradiology
Volume	32
Issue number	1
DOIs	https://doi.org/10.1007/BF00593948
State	Published - Jan 1990
Externally published	Yes

Keywords

Intrathecal diatrizoate meglumine
Lethal dysregulation

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10.1007/BF00593948

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title = "Fatal complications after myelography with meglumine diatrizoate",

abstract = "A case of inadvertent intrathecal injection of diatrizoate meglumine is presented. After myelography with 10 ml i.e. 6.5 g Angiografin, a 76-year-old man rapidly developed myoclonus, drowsiness and excessive metabolic acidosis. He died only a few hours later. Postmortem showed non-specific brain edema. RP-HPL-Chromatography confirmed high concentration of the contrast medium in CSF (6 mg/ml) which must have induced refractory central nervous dysregulation. The lethal effects of the misapplication of this agent on the nervous system are discussed.",

keywords = "Intrathecal diatrizoate meglumine, Lethal dysregulation",

author = "Hilz, {M. J.} and W. Huk and B. Schellmann and F. S{\"o}rgel and Druschky, {K. F.}",

year = "1990",

month = jan,

doi = "10.1007/BF00593948",

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volume = "32",

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T1 - Fatal complications after myelography with meglumine diatrizoate

AU - Hilz, M. J.

AU - Huk, W.

AU - Schellmann, B.

AU - Sörgel, F.

AU - Druschky, K. F.

PY - 1990/1

Y1 - 1990/1

N2 - A case of inadvertent intrathecal injection of diatrizoate meglumine is presented. After myelography with 10 ml i.e. 6.5 g Angiografin, a 76-year-old man rapidly developed myoclonus, drowsiness and excessive metabolic acidosis. He died only a few hours later. Postmortem showed non-specific brain edema. RP-HPL-Chromatography confirmed high concentration of the contrast medium in CSF (6 mg/ml) which must have induced refractory central nervous dysregulation. The lethal effects of the misapplication of this agent on the nervous system are discussed.

AB - A case of inadvertent intrathecal injection of diatrizoate meglumine is presented. After myelography with 10 ml i.e. 6.5 g Angiografin, a 76-year-old man rapidly developed myoclonus, drowsiness and excessive metabolic acidosis. He died only a few hours later. Postmortem showed non-specific brain edema. RP-HPL-Chromatography confirmed high concentration of the contrast medium in CSF (6 mg/ml) which must have induced refractory central nervous dysregulation. The lethal effects of the misapplication of this agent on the nervous system are discussed.

KW - Intrathecal diatrizoate meglumine

KW - Lethal dysregulation

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VL - 32

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EP - 73

JO - Neuroradiology

JF - Neuroradiology

IS - 1

ER -

Fatal complications after myelography with meglumine diatrizoate

Abstract

Keywords

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