Fast Spin‐Echo, Magnetic Resonance Imaging‐Measured Hippocampal Volume: Correlation with Neuronal Density in Anterior Temporal Lobectomy Patients

Namsoo Lee, Robert D. Tien, Darrell V. Lewis, Allan H. Friedman, Gary J. Felsberg, Barbara Crain, Christine Hulette, Alan K. Osumi, Jean S. Smith, Kevan E. VanLandingham, Rodney A. Radtke

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Summary: To assess the value of magnetic resonance imaging (MRI)‐measured hippocampal volume in the detection of hippocampal sclerosis, we studied 28 patients undergoing anterior temporal lobectomy for medically intractable mesial temporal lobe epilepsy. Hippocampal volumetry and visual analysis of T2 signal change were performed using fast spin‐echo T2‐weighted MRI. Quantitative neuronal density measurements were performed in the resected hippocampal specimens. There was a significant correlation between MRI‐measured absolute hippocampal volume (AHV) and neuronal density in CA1, CA2, and CA3 subfields (p<0. 0001, p < 0.01, and p < 0.05, respectively). Differential hippocampal volume (side‐to‐side volume difference) failed to detect bilateral atrophy in three patients, but the bilateral hippocampal atrophy was recognized by considering AHV in these patients. This study suggests that MRI‐measured AHV can be of value in evaluating patients with mesial temporal lobe epilepsy, especially when there is no side‐to‐side difference in hippocampal volumetry.

Original languageEnglish
Pages (from-to)899-904
Number of pages6
JournalEpilepsia
Volume36
Issue number9
DOIs
StatePublished - Sep 1995
Externally publishedYes

Keywords

  • FSE‐MRI–Hippocampal volumetry–Hippocampal sclerosis–Hippocampal volume–Neuronal density

Fingerprint

Dive into the research topics of 'Fast Spin‐Echo, Magnetic Resonance Imaging‐Measured Hippocampal Volume: Correlation with Neuronal Density in Anterior Temporal Lobectomy Patients'. Together they form a unique fingerprint.

Cite this