Fanconi's anemia and esophageal carcinoma

A. Sicular, P. R. Fleshner, L. B. Cohen, K. Hirschhorn, R. J. Matta

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Fanconi's anemia is a rare autosomal recessive disorder characterized by progressive pancytopenia, growth retardation, various congenital abnormalities and chromosomal breakage. Patients with this disorder are prone to develop leukemia, hepatoma, and later in life, squamous carcinoma. We describe the case of a 28-year-old patient with Fanconi's anemia diagnosed in his pre-adolescence, treated for 15 years with corticosteroids and androgens, who developed squamous esophageal carcinoma. In the absence of other identifiable risk factors for esophageal carcinoma, and the extraordinarily low frequency of this malignant condition in white males below the age of 30, we believe that the development of this disease is a late complication of Fanconi's anemia.

Original languageEnglish
Pages (from-to)60-63
Number of pages4
JournalGullet
Volume3
Issue number2
StatePublished - 1993

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