Family matters: Gene regulation by metal-dependent transcription factors

Harm van Bakel, Cisca Wijmenga

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Scopus citations


All organisms require trace amounts of metal ions, such as copper, iron, and zinc, since they form an essential component of a number of enzymes. In the past few years many metal-responsive transcriptional regulators have been identified in both prokaryotes and eukaryotes, which can be grouped in distinct families, based on their evolutionary and structural relationships. By regulating systems involved in metal uptake as well as metal efflux and sequestering, these transcription factors help to maintain a delicate balance between necessity and toxicity. Despite the structural similarities within the transcription factor families, individual members can have an affinity for different, and sometimes multiple, metal substrates. The recent availability of crystal structures for key members has led to a detailed understanding of the origins of metal specificity and the mechanisms of transcriptional activation for most of these transcription factor families.

Original languageEnglish
Title of host publicationMetal Homeotsasis and Detoxification
Subtitle of host publicationFrom Microbes to Man
EditorsMarkus Tamas, Enrico
Number of pages54
StatePublished - 2006
Externally publishedYes

Publication series

NameTopics in Current Genetics
ISSN (Print)1610-2096
ISSN (Electronic)1610-6970


Dive into the research topics of 'Family matters: Gene regulation by metal-dependent transcription factors'. Together they form a unique fingerprint.

Cite this