Family history in delusional depression

Lawrence H. Price; J. Craig Nelson; Dennis S. Charney; Donald M. Quinlan

doi:10.1016/0165-0327(84)90012-0

Family history in delusional depression

Lawrence H. Price
, J. Craig Nelson
, Dennis S. Charney
, Donald M. Quinlan

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Family psychiatric history was compared in the 472 first-degree relatives of 31 delusional and 35 nondelusional inpatients who met DSM III criteria for major depression with melancholia. Morbid risks for psychiatric illness or for psychiatric treatment variables did not differ between the two groups. Specifically, rates of affective and psychotic illness in families did not distinguish delusional from nondelusional probands. The findings do not support the hypothesis of a genetic relationship of nonaffective psychosis to delusional depression.

Original language	English
Pages (from-to)	109-114
Number of pages	6
Journal	Journal of Affective Disorders
Volume	6
Issue number	1
DOIs	https://doi.org/10.1016/0165-0327(84)90012-0
State	Published - Feb 1984
Externally published	Yes

Keywords

delusions
depression
family history
melancholia
psychiatric treatment

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10.1016/0165-0327(84)90012-0

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title = "Family history in delusional depression",

abstract = "Family psychiatric history was compared in the 472 first-degree relatives of 31 delusional and 35 nondelusional inpatients who met DSM III criteria for major depression with melancholia. Morbid risks for psychiatric illness or for psychiatric treatment variables did not differ between the two groups. Specifically, rates of affective and psychotic illness in families did not distinguish delusional from nondelusional probands. The findings do not support the hypothesis of a genetic relationship of nonaffective psychosis to delusional depression.",

keywords = "delusions, depression, family history, melancholia, psychiatric treatment",

author = "Price, \{Lawrence H.\} and Nelson, \{J. Craig\} and Charney, \{Dennis S.\} and Quinlan, \{Donald M.\}",

note = "Funding Information: Recent studies provide evidence that delusional unipolar depression constitutes a distinct subtype of affective illness. This possibility was raised by Glassman et al. (1975), who noted the limited effectiveness of tricyclic antidepressants in delusional unipolar depression. Subsequently, several investigators have documented the need for alternative treatment approaches to this disorder (Nelson and Bowers 1978; Minter and Mandel 1979a, b; Nelson et al. 1979; Kaskey et al. 1980; Charney and Nelson 1981; Brown et al. 1982; Perry et al., 1982; Price et al. 1983). These treatment response studies have been complemented by neurochemical studies This study was supported in part by the Yale Mental Health Clinical Research Center and NIMH Grant MH-30929. * To whom reprint requests should be sent.",

year = "1984",

month = feb,

doi = "10.1016/0165-0327(84)90012-0",

language = "English",

volume = "6",

pages = "109--114",

journal = "Journal of Affective Disorders",

issn = "0165-0327",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Family history in delusional depression

AU - Price, Lawrence H.

AU - Nelson, J. Craig

AU - Charney, Dennis S.

AU - Quinlan, Donald M.

N1 - Funding Information: Recent studies provide evidence that delusional unipolar depression constitutes a distinct subtype of affective illness. This possibility was raised by Glassman et al. (1975), who noted the limited effectiveness of tricyclic antidepressants in delusional unipolar depression. Subsequently, several investigators have documented the need for alternative treatment approaches to this disorder (Nelson and Bowers 1978; Minter and Mandel 1979a, b; Nelson et al. 1979; Kaskey et al. 1980; Charney and Nelson 1981; Brown et al. 1982; Perry et al., 1982; Price et al. 1983). These treatment response studies have been complemented by neurochemical studies This study was supported in part by the Yale Mental Health Clinical Research Center and NIMH Grant MH-30929. * To whom reprint requests should be sent.

PY - 1984/2

Y1 - 1984/2

N2 - Family psychiatric history was compared in the 472 first-degree relatives of 31 delusional and 35 nondelusional inpatients who met DSM III criteria for major depression with melancholia. Morbid risks for psychiatric illness or for psychiatric treatment variables did not differ between the two groups. Specifically, rates of affective and psychotic illness in families did not distinguish delusional from nondelusional probands. The findings do not support the hypothesis of a genetic relationship of nonaffective psychosis to delusional depression.

AB - Family psychiatric history was compared in the 472 first-degree relatives of 31 delusional and 35 nondelusional inpatients who met DSM III criteria for major depression with melancholia. Morbid risks for psychiatric illness or for psychiatric treatment variables did not differ between the two groups. Specifically, rates of affective and psychotic illness in families did not distinguish delusional from nondelusional probands. The findings do not support the hypothesis of a genetic relationship of nonaffective psychosis to delusional depression.

KW - delusions

KW - depression

KW - family history

KW - melancholia

KW - psychiatric treatment

UR - https://www.scopus.com/pages/publications/0021354161

U2 - 10.1016/0165-0327(84)90012-0

DO - 10.1016/0165-0327(84)90012-0

M3 - Article

C2 - 6231325

AN - SCOPUS:0021354161

SN - 0165-0327

VL - 6

SP - 109

EP - 114

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

IS - 1

ER -

Family history in delusional depression

Abstract

Keywords

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