TY - JOUR
T1 - Family-Genetic and Psychosocial Risk Factors in DSM-III Attention Deficit Disorder
AU - BIEDERMAN, JOSEPH
AU - FARAONE, STEPHEN V.
AU - KEENAN, KATE
AU - KNEE, DEBRA
AU - TSUANG, MING T.
N1 - Funding Information:
Accepted January 8, 1990. Dr. Biederman, Dr. Faraone, Ms. Keenan, and Ms. Knee are with the Pediatric Psychopharmacology Unit, Child Psychiatry Service, Massachusetts General Hospital and Harvard Medical School. Dr. Faraone and Dr. Tsuang are with the Psychiatry Service, BrocktonWest Roxbury VA Medical Center;Section ofPsychiatric Epidemiology and Genetics, Harvard Medical School; Department of Psychiatry, Massachusetts Mental Health Center. This work was supported, in part, by grants from the Charlupski Foundation (JB), as well as USPHS (NiMH) grant R01 MH-41314-01A2 (JB). The authors thank Dr. Kerim Munir and Virginia Wright, B.A., f or their help with this project, as well as Dr. Michael Jellinek for his encouragement. Partial abstracts and preliminary presentations ofsome material in this manuscript were presented at the Regional Meetings ofthe World Federation of Societies of Biological Psychiatry, Jerusalem, Israel, April 1989; the Annual Meeting ofthe Society ofBiological Psychiatry, San Francisco, May 1989; and the Annual Research Symposium, Massachusetts General Hospital, Boston, January 1989. Request reprints from Dr. Biederman, Pediatric Psychopharmacology Unit (ACC 725), Massachusetts General Hospital, Fruit Street, Boston, MA 02114. 0890-8567/90/2904-0526$02.00/0© 1990bytheAmericanAcademy of Child and Adolescent Psychiatry.
PY - 1990
Y1 - 1990
N2 - Using family study methodology and assessments made by blind raters, this study evaluated family-genetic and psychosocial risk factors for DSM-III attention deficit disorder (ADD) among the 457 first-degree relatives of clinically referred children and adolescents with ADD (N = 73), compared with psychiatric (N = 26) and normal controls (N = 26). Relatives of ADD probands had a higher morbidity risk for ADD (25.1% versus 5.3% versus 4.6%, ps < 0.00001), antisocial disorders (25.3% versus 6.9% versus 4.2%, ps < 0.00001), and mood disorders (27.1% versus 13.9%, p = 0.038 and 27.1% versus 3.6%, p = 0.00001) than did relatives of psychiatric and normal controls. The increased risk for ADD could not be accounted for by gender or generation of relative, the age of proband, social class, or the intactness of the family. These results confirm and extend previous findings indicating important family-genetic risk factors in ADD.
AB - Using family study methodology and assessments made by blind raters, this study evaluated family-genetic and psychosocial risk factors for DSM-III attention deficit disorder (ADD) among the 457 first-degree relatives of clinically referred children and adolescents with ADD (N = 73), compared with psychiatric (N = 26) and normal controls (N = 26). Relatives of ADD probands had a higher morbidity risk for ADD (25.1% versus 5.3% versus 4.6%, ps < 0.00001), antisocial disorders (25.3% versus 6.9% versus 4.2%, ps < 0.00001), and mood disorders (27.1% versus 13.9%, p = 0.038 and 27.1% versus 3.6%, p = 0.00001) than did relatives of psychiatric and normal controls. The increased risk for ADD could not be accounted for by gender or generation of relative, the age of proband, social class, or the intactness of the family. These results confirm and extend previous findings indicating important family-genetic risk factors in ADD.
KW - adolescents
KW - attention deficit disorder
KW - children
KW - family-genetic
KW - psychosocial
UR - http://www.scopus.com/inward/record.url?scp=0025324594&partnerID=8YFLogxK
U2 - 10.1097/00004583-199007000-00004
DO - 10.1097/00004583-199007000-00004
M3 - Article
C2 - 2387786
AN - SCOPUS:0025324594
SN - 0890-8567
VL - 29
SP - 526
EP - 533
JO - Journal of the American Academy of Child and Adolescent Psychiatry
JF - Journal of the American Academy of Child and Adolescent Psychiatry
IS - 4
ER -