@article{0bd0de43fa1346f5952f8b396ba47f76,
title = "Family-based association study of the BDNF, COMT and serotonin transporter genes and DSM-IV bipolar-I disorder in children",
abstract = "Background: Over the past decade pediatric bipolar disorder has gained recognition as a potentially more severe and heritable form of the disorder. In this report we test for association with genes coding brain-derived neurotrophic factor (BDNF), the serotonin transporter (SLC6A4), and catechol-O-methyltransferase (COMT). Methods: Bipolar-I affected offspring triads (N = 173) were drawn from 522 individuals with 2 parents in 332 nuclear families recruited for genetic studies of pediatric psychopathology at the Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD at Massachusetts General Hospital. Results: We failed to identify an association with the val66 allele in BDNF (OR = 1.23, p = 0.36), the COMT-l allele (OR = 1.27, p = 0.1), or the HTTLPR short allele (OR = 0.87, p = 0.38). Conclusion: Our study suggests that the markers examined thus far in COMT and SLC6A4 are not associated with pediatric bipolar disorder and that if the val66met marker in BDNF is associated with pediatric bipolar disorder the magnitude of the association is much smaller than first reported.",
author = "Eric Mick and Janet Wozniak and Wilens, \{Timothy E.\} and Joseph Biederman and Faraone, \{Stephen V.\}",
note = "Funding Information: This work was supported in part by National Institute Health (NIH) grants K01MH065523 to Dr Mick, K08MH001503 and R01MH066237 to Dr Wozniak, R01MH050657 and R01HD036317 to Dr Biederman, R01DA012945 to Dr Wilens, and R01MH57934, R01HD37694 and R01MH066877 to Dr Faraone. This work was also supported by a grant from the Heinz C. Prechter Bipolar Research Fund and the support of members of the MGH Pediatric Psychopharmacology Council. Funding Information: Dr. Faraone receives research support from and consults to Shire Pharmaceutical Development. He receives grant support from Eli Lilly and the National Institutes of Health. Funding Information: Dr. Eric Mick receives research support from the following sources: McNeil Pediatrics, Ortho-McNeil Janssen Scien- tific Affairs, Pfizer, Shire Pharmaceuticals, and the National Institute of Mental Health (NIMH) and has had an advisory or consulting relationship with Pfizer, Shire Pharmaceuticals and Validus Pharmaceuticals.",
year = "2009",
month = jan,
day = "4",
doi = "10.1186/1471-244X-9-2",
language = "English",
volume = "9",
journal = "BMC Psychiatry",
issn = "1471-244X",
publisher = "BioMed Central Ltd.",
}