TY - JOUR
T1 - Familial transmission of derived phenotypes for molecular genetic studies of substance use disorders
AU - Faraone, Stephen V.
AU - Adamson, Joel J.
AU - Wilens, Timothy E.
AU - Monuteaux, Michael C.
AU - Biederman, Joseph
N1 - Funding Information:
Funding source. This work was supported in part by grants to S. Faraone from the National Institute of Drug Abuse (R01MH57934).
PY - 2008/1/1
Y1 - 2008/1/1
N2 - Although family, twin, and adoption studies indicate that genes play a significant etiologic role in the development of substance use disorders (SUDs), detecting specific genes has been difficult due to uncertainties about how to define SUDs, genetic heterogeneity and variable phenotypic expression of SUD genotypes. We used data from families recruited into six contemporaneous studies of children and adults to derive candidate SUD phenotypes using principle factors factor analysis with varimax rotation. We previously found evidence of two SUD phenotypes in offspring: a psychopathology dimension and a cognitive impairment dimension. We found evidence for one SUD-related phenotype in adults that we term Psychopathology and Cognitive Impairment. Parental factor scores significantly predicted both offspring phenotypes, as well as parental SUD (OR = 1.41, p < 0.001) and offspring SUD (mother's phenotype: OR = 1.34, p = 0.04; father's phenotype: OR = 1.33, p = 0.01). Offspring phenotype predicted offspring SUD (psychopathology phenotype: OR = 2.96, p < 0.001; cognitive impairment: OR = 1.33, p = 0.04); in offspring, baseline psychopathology predicted SUD at follow-up assessments (OR = 1.55, p = 0.01). Results suggest that these candidate SUD phenotypes may be useful for genetic studies of SUD.
AB - Although family, twin, and adoption studies indicate that genes play a significant etiologic role in the development of substance use disorders (SUDs), detecting specific genes has been difficult due to uncertainties about how to define SUDs, genetic heterogeneity and variable phenotypic expression of SUD genotypes. We used data from families recruited into six contemporaneous studies of children and adults to derive candidate SUD phenotypes using principle factors factor analysis with varimax rotation. We previously found evidence of two SUD phenotypes in offspring: a psychopathology dimension and a cognitive impairment dimension. We found evidence for one SUD-related phenotype in adults that we term Psychopathology and Cognitive Impairment. Parental factor scores significantly predicted both offspring phenotypes, as well as parental SUD (OR = 1.41, p < 0.001) and offspring SUD (mother's phenotype: OR = 1.34, p = 0.04; father's phenotype: OR = 1.33, p = 0.01). Offspring phenotype predicted offspring SUD (psychopathology phenotype: OR = 2.96, p < 0.001; cognitive impairment: OR = 1.33, p = 0.04); in offspring, baseline psychopathology predicted SUD at follow-up assessments (OR = 1.55, p = 0.01). Results suggest that these candidate SUD phenotypes may be useful for genetic studies of SUD.
KW - Factor analysis
KW - Genetic studies
KW - Substance use disorders
UR - https://www.scopus.com/pages/publications/36849080410
U2 - 10.1016/j.drugalcdep.2007.07.002
DO - 10.1016/j.drugalcdep.2007.07.002
M3 - Article
C2 - 17766060
AN - SCOPUS:36849080410
SN - 0376-8716
VL - 92
SP - 100
EP - 107
JO - Drug and Alcohol Dependence
JF - Drug and Alcohol Dependence
IS - 1-3
ER -