Familial liability to schizophrenia and premorbid adjustment

Muriel Walshe; Mark Taylor; Katja Schulze; Elvira Bramon; Sophia Frangou; Daniel Stahl; Eugenia Kravariti; Eileen Daly; Paul Fearon; Robin M. Murray; Colm McDonald

doi:10.1192/bjp.bp.106.033688

Familial liability to schizophrenia and premorbid adjustment

Muriel Walshe, Mark Taylor, Katja Schulze, Elvira Bramon, Sophia Frangou, Daniel Stahl, Eugenia Kravariti, Eileen Daly, Paul Fearon, Robin M. Murray, Colm McDonald

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

We assessed premorbid functioning during childhood and adolescence in 50 people with schizophrenia from multiply affected families, 39 of their unaffected siblings, 69 people with schizophrenia with no family history of psychosis, 67 of their unaffected siblings and 83 controls. People with schizophrenia had poorer premorbid social and academic adjustment and exhibited a decline between childhood and adolescence compared with controls. Unaffected siblings from multiply affected families also had poor academic functioning in adolescence, with a decline between childhood and adolescence.This may represent a familial (presumed genetic) effect. Declaration of interest: None. E.B. and CM. supported by the Wellcome Trust.

Original language	English
Pages (from-to)	260-261
Number of pages	2
Journal	British Journal of Psychiatry
Volume	191
Issue number	3
DOIs	https://doi.org/10.1192/bjp.bp.106.033688
State	Published - Sep 2007
Externally published	Yes

Access to Document

10.1192/bjp.bp.106.033688

Cite this

@article{1b00ced4710f449989d4dff572d887b6,

title = "Familial liability to schizophrenia and premorbid adjustment",

abstract = "We assessed premorbid functioning during childhood and adolescence in 50 people with schizophrenia from multiply affected families, 39 of their unaffected siblings, 69 people with schizophrenia with no family history of psychosis, 67 of their unaffected siblings and 83 controls. People with schizophrenia had poorer premorbid social and academic adjustment and exhibited a decline between childhood and adolescence compared with controls. Unaffected siblings from multiply affected families also had poor academic functioning in adolescence, with a decline between childhood and adolescence.This may represent a familial (presumed genetic) effect. Declaration of interest: None. E.B. and CM. supported by the Wellcome Trust.",

author = "Muriel Walshe and Mark Taylor and Katja Schulze and Elvira Bramon and Sophia Frangou and Daniel Stahl and Eugenia Kravariti and Eileen Daly and Paul Fearon and Murray, {Robin M.} and Colm McDonald",

year = "2007",

month = sep,

doi = "10.1192/bjp.bp.106.033688",

language = "English",

volume = "191",

pages = "260--261",

journal = "British Journal of Psychiatry",

issn = "0007-1250",

publisher = "Cambridge University Press",

number = "3",

}

TY - JOUR

T1 - Familial liability to schizophrenia and premorbid adjustment

AU - Walshe, Muriel

AU - Taylor, Mark

AU - Schulze, Katja

AU - Bramon, Elvira

AU - Frangou, Sophia

AU - Stahl, Daniel

AU - Kravariti, Eugenia

AU - Daly, Eileen

AU - Fearon, Paul

AU - Murray, Robin M.

AU - McDonald, Colm

PY - 2007/9

Y1 - 2007/9

N2 - We assessed premorbid functioning during childhood and adolescence in 50 people with schizophrenia from multiply affected families, 39 of their unaffected siblings, 69 people with schizophrenia with no family history of psychosis, 67 of their unaffected siblings and 83 controls. People with schizophrenia had poorer premorbid social and academic adjustment and exhibited a decline between childhood and adolescence compared with controls. Unaffected siblings from multiply affected families also had poor academic functioning in adolescence, with a decline between childhood and adolescence.This may represent a familial (presumed genetic) effect. Declaration of interest: None. E.B. and CM. supported by the Wellcome Trust.

AB - We assessed premorbid functioning during childhood and adolescence in 50 people with schizophrenia from multiply affected families, 39 of their unaffected siblings, 69 people with schizophrenia with no family history of psychosis, 67 of their unaffected siblings and 83 controls. People with schizophrenia had poorer premorbid social and academic adjustment and exhibited a decline between childhood and adolescence compared with controls. Unaffected siblings from multiply affected families also had poor academic functioning in adolescence, with a decline between childhood and adolescence.This may represent a familial (presumed genetic) effect. Declaration of interest: None. E.B. and CM. supported by the Wellcome Trust.

UR - http://www.scopus.com/inward/record.url?scp=34548777455&partnerID=8YFLogxK

U2 - 10.1192/bjp.bp.106.033688

DO - 10.1192/bjp.bp.106.033688

M3 - Article

C2 - 17766769

AN - SCOPUS:34548777455

SN - 0007-1250

VL - 191

SP - 260

EP - 261

JO - British Journal of Psychiatry

JF - British Journal of Psychiatry

IS - 3

ER -

Familial liability to schizophrenia and premorbid adjustment

Abstract

Access to Document

Fingerprint

Cite this