Familial liability to schizophrenia and premorbid adjustment

Muriel Walshe, Mark Taylor, Katja Schulze, Elvira Bramon, Sophia Frangou, Daniel Stahl, Eugenia Kravariti, Eileen Daly, Paul Fearon, Robin M. Murray, Colm McDonald

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


We assessed premorbid functioning during childhood and adolescence in 50 people with schizophrenia from multiply affected families, 39 of their unaffected siblings, 69 people with schizophrenia with no family history of psychosis, 67 of their unaffected siblings and 83 controls. People with schizophrenia had poorer premorbid social and academic adjustment and exhibited a decline between childhood and adolescence compared with controls. Unaffected siblings from multiply affected families also had poor academic functioning in adolescence, with a decline between childhood and adolescence.This may represent a familial (presumed genetic) effect. Declaration of interest: None. E.B. and CM. supported by the Wellcome Trust.

Original languageEnglish
Pages (from-to)260-261
Number of pages2
JournalBritish Journal of Psychiatry
Issue number3
StatePublished - Sep 2007
Externally publishedYes


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