Familial, demyelinating sensory and motor polyneuropathy with conduction block

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Both multifocal, demyelinating features and prednisone responsiveness are rare in Charcot-Marie-Tooth (CMT) disease. We report a mother and son with a prednisone-responsive, multifocal, demyelinating, predominantly sensory polyneuropathy that was associated with an isoleucine92valine polymorphism of lipopolysaccharide-induced TNF-alpha factor (LITAF). The mother had a multifocal, acquired, demyelinating sensory and motor polyneuropathy (MADSAM)-like presentation. The son developed left peroneal neuropathy during acute Lyme disease with a subsequent relapsing, MADSAM-like illness, despite antibiotic treatment. Both shared prednisone responsiveness and multifocal, demyelinating features electrophysiologically. MADSAM may be familial (FaDSAM) and respond to prednisone.

Original languageEnglish
Pages (from-to)558-562
Number of pages5
JournalMuscle and Nerve
Issue number4
StatePublished - Apr 2010
Externally publishedYes


  • Charcot-marie-tooth disease
  • Hereditary
  • Lewis-sumner syndrome
  • Polyneuropathy


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