Familial Crohn's disease in multiple siblings: No linkage to the HLA system

J. F. Colombel; F. Guillemot; A. Van Gossum; F. Dufosse; A. Cortot; E. Dupont; J. C. Paris

Familial Crohn's disease in multiple siblings: No linkage to the HLA system

J. F. Colombel, F. Guillemot, A. Van Gossum, F. Dufosse, A. Cortot, E. Dupont, J. C. Paris

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16 Scopus citations

Abstract

We report five families with 3 or more children having Crohn's disease. In one family, 6 out of 11 siblings were affected. HLA haplotype study in affected children showed that the probability of random segregation was only 38 percent, making improbable a linkage between the histocompatibility locus and the development of Crohn's disease. However similar clinical patterns in siblings could suggest a genetic factor not linked to the HLA system.

Original language	English
Pages (from-to)	676-678
Number of pages	3
Journal	Gastroenterologie Clinique et Biologique
Volume	13
Issue number	8-9
State	Published - 1989
Externally published	Yes

Cite this

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title = "Familial Crohn's disease in multiple siblings: No linkage to the HLA system",

abstract = "We report five families with 3 or more children having Crohn's disease. In one family, 6 out of 11 siblings were affected. HLA haplotype study in affected children showed that the probability of random segregation was only 38 percent, making improbable a linkage between the histocompatibility locus and the development of Crohn's disease. However similar clinical patterns in siblings could suggest a genetic factor not linked to the HLA system.",

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AU - Colombel, J. F.

AU - Guillemot, F.

AU - Van Gossum, A.

AU - Dufosse, F.

AU - Cortot, A.

AU - Dupont, E.

AU - Paris, J. C.

PY - 1989

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AB - We report five families with 3 or more children having Crohn's disease. In one family, 6 out of 11 siblings were affected. HLA haplotype study in affected children showed that the probability of random segregation was only 38 percent, making improbable a linkage between the histocompatibility locus and the development of Crohn's disease. However similar clinical patterns in siblings could suggest a genetic factor not linked to the HLA system.

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JO - Gastroenterologie Clinique et Biologique

JF - Gastroenterologie Clinique et Biologique

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Familial Crohn's disease in multiple siblings: No linkage to the HLA system

Abstract

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