Familial association of pancreatic cancer with other malignancies in Swedish families

E. Hiripi, J. Lorenzo Bermejo, X. Li, J. Sundquist, K. Hemminki

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Background:The aim of this study was to characterise the familial association of pancreatic cancer with other malignancies.Methods:Relative risks (RRs) of pancreatic cancer according to family history of cancer were calculated using the updated Swedish Family-Cancer Database, which includes over 11.5 million individuals. Estimates were based on Poisson regression. RRs of tumours for individuals with a parental history of pancreatic cancer were also estimated.Results:The risk of pancreatic cancer was elevated in individuals with a parental history of cancers of the liver (RR 1.41; 95% CI 1.10-1.81), kidney (RR 1.37; 95% CI 1.06-1.76), lung (RR 1.50; 95% CI 1.27-1.79) and larynx (RR 1.98; 95% CI 1.19-3.28). Associations were also found between parental history of pancreatic cancer and cancers of the small intestine, colon, breast, lung, testis and cervix in offspring. There was an increased risk of pancreatic cancer associated with early-onset breast cancer in siblings.Conclusion:Pancreatic cancer aggregates in families with several types of cancer. Smoking may contribute to the familial aggregation of pancreatic and lung tumours, and the familial clustering of pancreatic and breast cancer could be partially explained by inherited mutations in the BRCA2 gene.

Original languageEnglish
Pages (from-to)1792-1797
Number of pages6
JournalBritish Journal of Cancer
Volume101
Issue number10
DOIs
StatePublished - Nov 2009
Externally publishedYes

Keywords

  • Familial risk
  • Family history
  • Pancreatic cancer

Fingerprint

Dive into the research topics of 'Familial association of pancreatic cancer with other malignancies in Swedish families'. Together they form a unique fingerprint.

Cite this