Failure to replicate influence of GRIK4 and GNB3 polymorphisms on treatment outcome in major depression

Alessandro Serretti; Alberto Chiesa; Concetta Crisafulli; Isabelle Massat; Sylvie Linotte; Raffaella Calati; Siegfried Kasper; Ursula Bailer; Yves Lecrubier; Martin Fink; Irina Antonijevic; Carlos Forray; Lenore Snyder; Joseph Bollen; Joseph Zohar; Diana De Ronchi; Daniel Souery; Julien Mendlewicz

doi:10.1159/000329553

Failure to replicate influence of GRIK4 and GNB3 polymorphisms on treatment outcome in major depression

Alessandro Serretti
, Alberto Chiesa
, Concetta Crisafulli
, Isabelle Massat
, Sylvie Linotte
, Raffaella Calati
, Siegfried Kasper
, Ursula Bailer
, Yves Lecrubier
, Martin Fink
, Irina Antonijevic
, Carlos Forray
, Lenore Snyder
, Joseph Bollen
, Joseph Zohar
, Diana De Ronchi
, Daniel Souery
, Julien Mendlewicz

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

In the present study, we aimed to confirm the previous finding of an association between GRIK4 and GNB3 variants (rs195478 and rs5443) and remission and treatment resistance in major depression, using a multicenter sample of 223 patients. We did not find any supporting evidence for such associations. These conflicting data may result from difficulties in the replication of candidate gene association studies.

Original language	English
Pages (from-to)	70-75
Number of pages	6
Journal	Neuropsychobiology
Volume	65
Issue number	2
DOIs	https://doi.org/10.1159/000329553
State	Published - Feb 2012
Externally published	Yes

Keywords

GNB3
GRIK4
Major depressive disorder

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10.1159/000329553

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Serretti, A., Chiesa, A., Crisafulli, C., Massat, I., Linotte, S., Calati, R., Kasper, S., Bailer, U., Lecrubier, Y., Fink, M., Antonijevic, I., Forray, C., Snyder, L., Bollen, J., Zohar, J., De Ronchi, D., Souery, D., & Mendlewicz, J. (2012). Failure to replicate influence of GRIK4 and GNB3 polymorphisms on treatment outcome in major depression. Neuropsychobiology, 65(2), 70-75. https://doi.org/10.1159/000329553

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abstract = "In the present study, we aimed to confirm the previous finding of an association between GRIK4 and GNB3 variants (rs195478 and rs5443) and remission and treatment resistance in major depression, using a multicenter sample of 223 patients. We did not find any supporting evidence for such associations. These conflicting data may result from difficulties in the replication of candidate gene association studies.",

keywords = "GNB3, GRIK4, Major depressive disorder",

author = "Alessandro Serretti and Alberto Chiesa and Concetta Crisafulli and Isabelle Massat and Sylvie Linotte and Raffaella Calati and Siegfried Kasper and Ursula Bailer and Yves Lecrubier and Martin Fink and Irina Antonijevic and Carlos Forray and Lenore Snyder and Joseph Bollen and Joseph Zohar and \{De Ronchi\}, Diana and Daniel Souery and Julien Mendlewicz",

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Serretti, A, Chiesa, A, Crisafulli, C, Massat, I, Linotte, S, Calati, R, Kasper, S, Bailer, U, Lecrubier, Y, Fink, M, Antonijevic, I, Forray, C, Snyder, L, Bollen, J, Zohar, J, De Ronchi, D, Souery, D & Mendlewicz, J 2012, 'Failure to replicate influence of GRIK4 and GNB3 polymorphisms on treatment outcome in major depression', Neuropsychobiology, vol. 65, no. 2, pp. 70-75. https://doi.org/10.1159/000329553

TY - JOUR

T1 - Failure to replicate influence of GRIK4 and GNB3 polymorphisms on treatment outcome in major depression

AU - Serretti, Alessandro

AU - Chiesa, Alberto

AU - Crisafulli, Concetta

AU - Massat, Isabelle

AU - Linotte, Sylvie

AU - Calati, Raffaella

AU - Kasper, Siegfried

AU - Bailer, Ursula

AU - Lecrubier, Yves

AU - Fink, Martin

AU - Antonijevic, Irina

AU - Forray, Carlos

AU - Snyder, Lenore

AU - Bollen, Joseph

AU - Zohar, Joseph

AU - De Ronchi, Diana

AU - Souery, Daniel

AU - Mendlewicz, Julien

PY - 2012/2

Y1 - 2012/2

N2 - In the present study, we aimed to confirm the previous finding of an association between GRIK4 and GNB3 variants (rs195478 and rs5443) and remission and treatment resistance in major depression, using a multicenter sample of 223 patients. We did not find any supporting evidence for such associations. These conflicting data may result from difficulties in the replication of candidate gene association studies.

AB - In the present study, we aimed to confirm the previous finding of an association between GRIK4 and GNB3 variants (rs195478 and rs5443) and remission and treatment resistance in major depression, using a multicenter sample of 223 patients. We did not find any supporting evidence for such associations. These conflicting data may result from difficulties in the replication of candidate gene association studies.

KW - GNB3

KW - GRIK4

KW - Major depressive disorder

UR - https://www.scopus.com/pages/publications/84855389473

U2 - 10.1159/000329553

DO - 10.1159/000329553

M3 - Article

C2 - 22222462

AN - SCOPUS:84855389473

SN - 0302-282X

VL - 65

SP - 70

EP - 75

JO - Neuropsychobiology

JF - Neuropsychobiology

IS - 2

ER -

Failure to replicate influence of GRIK4 and GNB3 polymorphisms on treatment outcome in major depression

Abstract

Keywords

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