Failure to detect Borna disease virus infection in peripheral blood leukocytes from humans with psychiatric disorders

J. A. Richt; R. C. Alexander; S. Herzog; D. C. Hooper; R. Kean; S. Spitsin; K. Bechter; R. Schüttler; H. Feldmann; A. Heiske; Z. F. Fu; B. Dietzschold; R. Rott; H. Koprowski

doi:10.3109/13550289709015807

Failure to detect Borna disease virus infection in peripheral blood leukocytes from humans with psychiatric disorders

J. A. Richt, R. C. Alexander, S. Herzog, D. C. Hooper, R. Kean, S. Spitsin, K. Bechter, R. Schüttler, H. Feldmann, A. Heiske, Z. F. Fu, B. Dietzschold, R. Rott, H. Koprowski

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

The presence of antibodies reactive with Borna disease virus (BDV) in the sera of some patients with certain psychiatric illnesses has been taken as evidence that this veterinary neurotrophic virus may occasionally infect and cause psychiatric disorders in humans. In this paper, we report the results of our studies concerning the detection of BDV-specific RNA in blood cells from patients with psychiatric diseases. Contrary to the results obtained by others, we have found no evidence for the presence of BDV-RNA in such cells. Prior work with BDV sequences in the assay environment, together with the exquisite sensitivity of RT-PCR, may account for the sporadic appearance of false positive evidence that BDV-specific RNA is present in human blood cells.

Original language	English
Pages (from-to)	174-178
Number of pages	5
Journal	Journal of NeuroVirology
Volume	3
Issue number	2
DOIs	https://doi.org/10.3109/13550289709015807
State	Published - Apr 1997
Externally published	Yes

Keywords

Borna disease virus
PBLs
Psychiatric disease
RT-PCR

Access to Document

10.3109/13550289709015807

Cite this

Richt, J. A., Alexander, R. C., Herzog, S., Hooper, D. C., Kean, R., Spitsin, S., Bechter, K., Schüttler, R., Feldmann, H., Heiske, A., Fu, Z. F., Dietzschold, B., Rott, R., & Koprowski, H. (1997). Failure to detect Borna disease virus infection in peripheral blood leukocytes from humans with psychiatric disorders. Journal of NeuroVirology, 3(2), 174-178. https://doi.org/10.3109/13550289709015807

@article{0b37034b2e8642efa1e3b507f77abfc4,

title = "Failure to detect Borna disease virus infection in peripheral blood leukocytes from humans with psychiatric disorders",

abstract = "The presence of antibodies reactive with Borna disease virus (BDV) in the sera of some patients with certain psychiatric illnesses has been taken as evidence that this veterinary neurotrophic virus may occasionally infect and cause psychiatric disorders in humans. In this paper, we report the results of our studies concerning the detection of BDV-specific RNA in blood cells from patients with psychiatric diseases. Contrary to the results obtained by others, we have found no evidence for the presence of BDV-RNA in such cells. Prior work with BDV sequences in the assay environment, together with the exquisite sensitivity of RT-PCR, may account for the sporadic appearance of false positive evidence that BDV-specific RNA is present in human blood cells.",

keywords = "Borna disease virus, PBLs, Psychiatric disease, RT-PCR",

author = "Richt, {J. A.} and Alexander, {R. C.} and S. Herzog and Hooper, {D. C.} and R. Kean and S. Spitsin and K. Bechter and R. Sch{\"u}ttler and H. Feldmann and A. Heiske and Fu, {Z. F.} and B. Dietzschold and R. Rott and H. Koprowski",

year = "1997",

month = apr,

doi = "10.3109/13550289709015807",

language = "English",

volume = "3",

pages = "174--178",

journal = "Journal of NeuroVirology",

issn = "1355-0284",

publisher = "Taylor and Francis Ltd.",

number = "2",

}

Richt, JA, Alexander, RC, Herzog, S, Hooper, DC, Kean, R, Spitsin, S, Bechter, K, Schüttler, R, Feldmann, H, Heiske, A, Fu, ZF, Dietzschold, B, Rott, R & Koprowski, H 1997, 'Failure to detect Borna disease virus infection in peripheral blood leukocytes from humans with psychiatric disorders', Journal of NeuroVirology, vol. 3, no. 2, pp. 174-178. https://doi.org/10.3109/13550289709015807

TY - JOUR

T1 - Failure to detect Borna disease virus infection in peripheral blood leukocytes from humans with psychiatric disorders

AU - Richt, J. A.

AU - Alexander, R. C.

AU - Herzog, S.

AU - Hooper, D. C.

AU - Kean, R.

AU - Spitsin, S.

AU - Bechter, K.

AU - Schüttler, R.

AU - Feldmann, H.

AU - Heiske, A.

AU - Fu, Z. F.

AU - Dietzschold, B.

AU - Rott, R.

AU - Koprowski, H.

PY - 1997/4

Y1 - 1997/4

N2 - The presence of antibodies reactive with Borna disease virus (BDV) in the sera of some patients with certain psychiatric illnesses has been taken as evidence that this veterinary neurotrophic virus may occasionally infect and cause psychiatric disorders in humans. In this paper, we report the results of our studies concerning the detection of BDV-specific RNA in blood cells from patients with psychiatric diseases. Contrary to the results obtained by others, we have found no evidence for the presence of BDV-RNA in such cells. Prior work with BDV sequences in the assay environment, together with the exquisite sensitivity of RT-PCR, may account for the sporadic appearance of false positive evidence that BDV-specific RNA is present in human blood cells.

AB - The presence of antibodies reactive with Borna disease virus (BDV) in the sera of some patients with certain psychiatric illnesses has been taken as evidence that this veterinary neurotrophic virus may occasionally infect and cause psychiatric disorders in humans. In this paper, we report the results of our studies concerning the detection of BDV-specific RNA in blood cells from patients with psychiatric diseases. Contrary to the results obtained by others, we have found no evidence for the presence of BDV-RNA in such cells. Prior work with BDV sequences in the assay environment, together with the exquisite sensitivity of RT-PCR, may account for the sporadic appearance of false positive evidence that BDV-specific RNA is present in human blood cells.

KW - Borna disease virus

KW - PBLs

KW - Psychiatric disease

KW - RT-PCR

UR - http://www.scopus.com/inward/record.url?scp=0030894432&partnerID=8YFLogxK

U2 - 10.3109/13550289709015807

DO - 10.3109/13550289709015807

M3 - Article

C2 - 9111180

AN - SCOPUS:0030894432

SN - 1355-0284

VL - 3

SP - 174

EP - 178

JO - Journal of NeuroVirology

JF - Journal of NeuroVirology

IS - 2

ER -

Failure to detect Borna disease virus infection in peripheral blood leukocytes from humans with psychiatric disorders

Abstract

Keywords

Access to Document

Fingerprint

Cite this