Failure of the ubiquitin proteasome system in Parkinson's disease

Kevin St P. McNaught, C. Warren Olanow, Barry Halliwell, Ole Isacson, Peter Jenner

Research output: Contribution to journalArticlepeer-review

477 Scopus citations

Abstract

Parkinson's disease (PD) is a neurodegenerative movement disorder characterized by degeneration of dopamine-containing neurons in the midbrain. In cases of familial PD, mutations that lead to failure of the ubiquitin proteasome system (UPS) have been identified. These genetic abnormalities do not occur in sporadic PD, but we propose that impairment of the UPS could also contribute to neurodegeneration in this disorder. We discuss evidence that failure of the UPS is a common aetiopathogenic factor that underlies the development of familial and sporadic PD, an idea that might help to explain clinical and pathological differences and similarities in these disorders.

Original languageEnglish
Pages (from-to)589-594
Number of pages6
JournalNature Reviews Neuroscience
Volume2
Issue number8
DOIs
StatePublished - Aug 2001

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