Factors associated with the sensitivity of fine-needle aspiration cytology for the diagnosis of follicular variant papillary thyroid carcinoma

Young Jun Chai, Hyunsuk Suh, Jin Wook Yi, Hyeong Won Yu, Joon Hyop Lee, Su Jin Kim, Jae Kyung Won, Kyu Eun Lee

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background The purpose of this study was to evaluate the factors associated with diagnostic accuracy of preoperative fine-needle aspiration (FNA) for follicular variant papillary thyroid carcinoma (FVPTC). Methods The patients with FVPTC who underwent thyroidectomy were divided into 2 groups: "group A" (Bethesda category II, III, or IV) versus "group B" (category V or VI). Results A total of 225 patients (117 in group A and 108 in group B) were included. Group B was associated with older age, malignant ultrasonographic features, smaller tumor size, extrathyroidal extension, higher stage, and B-type Raf (BRAF)V600E mutation compared with group A. In multivariable analysis, malignant ultrasonographic features and tumor size ≤3.0 cm were independent predictive factors for group B. Conclusion FVPTCs >3.0 cm are unlikely to be diagnosed as category V or VI. Clinicians should keep FVPTC in mind and consider diagnostic lobectomy for the nodules regardless of FNA or ultrasonographic findings.

Original languageEnglish
Pages (from-to)E1467-E1471
JournalHead and Neck
Volume38
DOIs
StatePublished - 1 Apr 2016

Keywords

  • diagnostic lobectomy
  • fine-needle aspiration
  • follicular variant
  • sensitivity of fine-needle aspiration
  • thyroid carcinoma

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