TY - JOUR
T1 - Factors Associated With Retinal Vessel Diameters in an Elderly Population
T2 - The Thessaloniki Eye Study
AU - Dervenis, Nikolaos
AU - Coleman, Anne L.
AU - Harris, Alon
AU - Wilson, M. Roy
AU - Yu, Fei
AU - Anastasopoulos, Eleftherios
AU - Founti, Panayiota
AU - Pappas, Theofanis
AU - Kilintzis, Vassilis
AU - Topouzis, Fotis
N1 - Publisher Copyright:
© 2019 The Authors.
PY - 2019/5
Y1 - 2019/5
N2 - PURPOSE. To identify the factors associated with retinal vessel diameters in the population of the Thessaloniki Eye Study. METHODS. Cross-sectional population-based study (age ≥ 60 years). Subjects with glaucoma, late age-related macular degeneration, and diabetic retinopathy were excluded from the analyses. Retinal vessel diameters were measured using the IVAN software, and measurements were summarized to central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE), and arteriole to venule ratio (AVR). RESULTS. The analysis included 1614 subjects. The hypertensive group showed lower values of CRAE (P = 0.033) and AVR (P = 0.0351) compared to the normal blood pressure (BP) group. On the contrary, the group having normal BP under antihypertensive treatment did not have different values compared to the normal BP group. Diastolic BP (per mm Hg) was negatively associated with CRAE (P < 0.0001) and AVR (P < 0.0001), while systolic BP (per mm Hg) was positively associated with CRAE (P = 0.001) and AVR (P = 0.0096). Other factors significantly associated included age, sex, alcohol, smoking, cardiovascular disease history, ophthalmic medication, weight, and IOP; differences were observed in a stratified analysis based on BP medication use. CONCLUSIONS. Our study confirms previous reports about the association of age and BP with vessel diameters. The negative correlation between BP and CRAE seems to be guided by the effect of diastolic BP as higher systolic BP is independently associated with higher values of CRAE. The association of BP status with retinal vessel diameters is determined by diastolic BP status in our population. Multiple other factors are also independently associated with retinal vessel diameters.
AB - PURPOSE. To identify the factors associated with retinal vessel diameters in the population of the Thessaloniki Eye Study. METHODS. Cross-sectional population-based study (age ≥ 60 years). Subjects with glaucoma, late age-related macular degeneration, and diabetic retinopathy were excluded from the analyses. Retinal vessel diameters were measured using the IVAN software, and measurements were summarized to central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE), and arteriole to venule ratio (AVR). RESULTS. The analysis included 1614 subjects. The hypertensive group showed lower values of CRAE (P = 0.033) and AVR (P = 0.0351) compared to the normal blood pressure (BP) group. On the contrary, the group having normal BP under antihypertensive treatment did not have different values compared to the normal BP group. Diastolic BP (per mm Hg) was negatively associated with CRAE (P < 0.0001) and AVR (P < 0.0001), while systolic BP (per mm Hg) was positively associated with CRAE (P = 0.001) and AVR (P = 0.0096). Other factors significantly associated included age, sex, alcohol, smoking, cardiovascular disease history, ophthalmic medication, weight, and IOP; differences were observed in a stratified analysis based on BP medication use. CONCLUSIONS. Our study confirms previous reports about the association of age and BP with vessel diameters. The negative correlation between BP and CRAE seems to be guided by the effect of diastolic BP as higher systolic BP is independently associated with higher values of CRAE. The association of BP status with retinal vessel diameters is determined by diastolic BP status in our population. Multiple other factors are also independently associated with retinal vessel diameters.
KW - Aging
KW - Epidemiology
KW - Hypertension
KW - Population-based
KW - Retinal vasculature
UR - http://www.scopus.com/inward/record.url?scp=85066432436&partnerID=8YFLogxK
U2 - 10.1167/iovs.18-26276
DO - 10.1167/iovs.18-26276
M3 - Article
C2 - 31108551
AN - SCOPUS:85066432436
SN - 0146-0404
VL - 60
SP - 2208
EP - 2217
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
IS - 6
ER -