Factors associated with caregiver compliance to an HIV disclosure intervention and its effect on HIV and mental health outcomes among children living with HIV: post-hoc instrumental variable-based analysis of a cluster randomized trial in Eldoret, Kenya

Elizabeth B. Magill, Winstone Nyandiko, Aaron Baum, Josephine Aluoch, Ashley Chory, Celestine Ashimoshi, Janet Lidweye, Tabitha Njoroge, Festus Sang, Jack Nyagaya, Michael Scanlon, Joseph Hogan, Rachel Vreeman

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The HADITHI study is a cluster-randomized trial of children living with HIV and their caregivers in Kenya that aimed to increase rates of caregiver disclosure of their child's HIV status, encourage earlier status disclosure, and improve pediatric mental health and HIV outcomes. This analysis identified characteristics predicting caregiver non-responsiveness and compared outcomes among children based on disclosure status. Methods: A penalized logistic regression model with lasso regularization identified the most important predictors of disclosure. The two-stage least squares instrumental variable approach was used to assess outcomes accounting for non-compliance to disclosure. Results: Caregiver non-isolation and shorter time on antiretroviral therapy were predictive of HIV status disclosure. There were no statistically significant differences found in CD4 percentage, depression status, or mental and emotional status based on disclosure status up to 24 months-post intervention. Conclusion: These findings have implications for specialists seeking to tailor disclosure interventions to improve caregiver-child dyad responsiveness.

Original languageEnglish
Article number1150744
JournalFrontiers in Public Health
Volume11
DOIs
StatePublished - 2023

Keywords

  • HIV status disclosure
  • Kenya
  • caregiver intervention
  • mental health
  • pediatric HIV

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