TY - JOUR
T1 - Factors affecting overdrive suppression of idioventricular pacemakers and associated potassium shifts
AU - Krellenstein, Daniel J.
AU - Pliam, Michael B.
AU - Brooks, Chandler Mc C.
AU - Vassalle, Mario
N1 - Funding Information:
A characterization of the factors controlling overdrive suppression of idioventricular pacemakers was investigated in canine hearts with complete atrioventricular block perfused in vitro. The following results were obtained: 1) overdrive suppression increases as a function of driving rate in a sigmoidal fashion; 2) overdrive suppression is maximal after 3 min; 3) the pause is a function of spontaneous rate prior to overdrive; 4) overdrive causes an initial net K loss; 5) overdrive is followed by a transient net K gain; 6) increasing \[K\]od oes not affect K loss; 7) net K loss with drive is less in pre-driven hearts; 8) net K uptake after overdrive is little affected by ventricular activity; 9) acetylcholine does not alter ventricular K balance; and 10) paired stimulation increases overdrive suppression and K loss whether or not each stimulus is followed by a contraction. The following conclusions are drawn. The factors controlling overdrive suppression include the spontaneous rate prior to drive, the rate, duration and pattern of drive, an increase in \[K\]od ur-ing the drive and a decrease in \[K\]oa fter From the Department of Physiology, State University of New York, Downstate Medical Center, Brooklyn, New York. *Research Assistant Professor of Surgery, Department of Surgery, Mt. Sinai Hospital, New York, New York. CResident in Cardiothoracic Surgery, Department of Cardiothoracic Surgery, The University of Utah Medical Center, Salt Lake City, Utah. **Distinguished Professor, Department of Physiology, State University of New York, Downstate Medical Center, Brooklyn, New York. $Professor of Physiology, Department of Physiology, State University of New York, Downstate Medical Center, Brooklyn, New York. Supported by grants from the New York Heart Association and from the National Institutes of Health. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "Advertisement" in accordance with 18 U.S.C. w solely to indicate this fact. Reprint requests to: Dr. Mario Vassalle, Department of Physiology-Box 31, Downstate Medical Center, 450 Clarkson Ave., Brooklyn, NY 11203.
PY - 1978
Y1 - 1978
N2 - A characterization of the factors controlling overdrive suppression of idioventricular pacemakers was investigated in canine hearts with complete atrioventricular block perfused in vitro. The following results were obtained: 1) overdrive suppression increases as a function of driving rate in a sigmoidal fashion; 2) overdrive suppression is maximal after 3 min; 3) the pause is a function of spontaneous rate prior to overdrive; 4) overdrive causes an initial net K loss; 5) overdrive is followed by a transient net K gain; 6) increasing [K]o does not affect K loss; 7) net K loss with drive is less in pre-driven hearts; 8) net K uptake after overdrive is little affected by ventricular activity; 9) acetylcholine does not alter ventricular K balance; and 10) paired stimulation increases overdrive suppression and K loss whether or not each stimulus is followed by a contraction. The following conclusions are drawn. The factors controlling overdrive suppression include the spontaneous rate prior to drive, the rate, duration and pattern of drive, an increase in [K]o during the drive and a decrease in [K]o after drive, but not an acetylcholine-mediated inhibition.
AB - A characterization of the factors controlling overdrive suppression of idioventricular pacemakers was investigated in canine hearts with complete atrioventricular block perfused in vitro. The following results were obtained: 1) overdrive suppression increases as a function of driving rate in a sigmoidal fashion; 2) overdrive suppression is maximal after 3 min; 3) the pause is a function of spontaneous rate prior to overdrive; 4) overdrive causes an initial net K loss; 5) overdrive is followed by a transient net K gain; 6) increasing [K]o does not affect K loss; 7) net K loss with drive is less in pre-driven hearts; 8) net K uptake after overdrive is little affected by ventricular activity; 9) acetylcholine does not alter ventricular K balance; and 10) paired stimulation increases overdrive suppression and K loss whether or not each stimulus is followed by a contraction. The following conclusions are drawn. The factors controlling overdrive suppression include the spontaneous rate prior to drive, the rate, duration and pattern of drive, an increase in [K]o during the drive and a decrease in [K]o after drive, but not an acetylcholine-mediated inhibition.
UR - https://www.scopus.com/pages/publications/0017844529
U2 - 10.1016/S0022-0736(78)80022-3
DO - 10.1016/S0022-0736(78)80022-3
M3 - Article
C2 - 621454
AN - SCOPUS:0017844529
SN - 0022-0736
VL - 11
SP - 3
EP - 10
JO - Journal of Electrocardiology
JF - Journal of Electrocardiology
IS - 1
ER -