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Factors affecting heterogeneity in breast cancer microenvironment: A narrative mini review

  • Anirban Ganguly
  • , Sumit Mukherjee
  • , Kaushiki Chatterjee
  • , Sheila Spada

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

4 Scopus citations

Abstract

Breast cancer (BC) heterogeneity is a key trait of BC tumors with crucial implications on tumorigenesis, diagnosis, and therapeutic modalities. It is influenced by tumor intrinsic features and by the tumor microenvironment (TME) composition of different intra-tumoral regions, which in turn affect cancer progression within patients. In this mini review, we will highlight the mechanisms that generate cancer heterogeneity in BC and how they affect the responses to cancer therapies.

Original languageEnglish
Title of host publicationTargeting Signaling Pathways in Solid Tumors - Part A
EditorsSumit Mukherjee, Kaushiki Chatterjee
PublisherElsevier Inc.
Pages211-226
Number of pages16
ISBN (Print)9780443235467
DOIs
StatePublished - Jan 2024
Externally publishedYes

Publication series

NameInternational Review of Cell and Molecular Biology
Volume385
ISSN (Print)1937-6448

Keywords

  • CAR-T cells
  • Epigenetics
  • Immune cell distribution
  • Immune checkpoint blockade
  • Immunotherapy
  • Matrix remodeling
  • Solid tumor
  • Tumor heterogeneity

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