Factor VII hyperactivity and mitral ring calcification in elderly women

T. Kuroda, K. Kario, M. Nishinaga, M. Yamasawa, S. Kim, T. Goto, H. Fukazawa, N. Nagou, K. Kayaba, K. Shimada

Research output: Contribution to journalArticlepeer-review


The level of coagulation factor VII activity (FVIIc) and prevalence of mitral ring calcification are significantly higher in elderly women than in elderly men. However, the role of gender in the differences is still largely unknown. We investigated the relationship between the FVIIc level and degree of mitral ring calcification in 243 community residents older than 60 years of age (male/female: 123/120, mean age: 78, range: 60-97 years) by two- dimensional echocardiography. Several other factors such as body mass index, systolic and diastolic blood pressures, FVIIc, fibrinogen, lipoprotein (a) [Lp (a)], total cholesterol, triglycerides and HDL-cholesterol were also measured. Mitral ring calcification was defined as absent (-), mild (localized: +), or moderate/severe (extended: ++). Calcification was detected in 20 males (+ 17, ++ 3) and 40 females (+ 28, ++ 12) (p < 0.001). The male (-) and (+, ++) groups showed no significant difference in parameters other than age. The female (-) and (+, ++) groups showed significant differences in age, systolic blood pressure, Lp (a), FVIIc and total cholesterol. In 63 women of older than 75 years of age, significant differences in Lp (a), FVIIc and total cholesterol were recognized. Multivariate analysis using a logistic model revealed a significant difference in FVIIc. These results suggest that FVII hyperactivity is closely related to the formation of mitral ring calcification in elderly women.

Original languageEnglish
Pages (from-to)45-50
Number of pages6
JournalJournal of Cardiology
Issue numberSUPPL. 1
StatePublished - 1995
Externally publishedYes


  • aging
  • atherosclerosis
  • epidemiologic methods
  • factor VII
  • mitral valve (ring calcification)
  • thromboembolism


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