TY - JOUR
T1 - Facing an un-met need in lung cancer screening
T2 - The never smokers
AU - Arrieta, Oscar
AU - Arroyo-Hernández, Marisol
AU - Soberanis-Piña, Pamela Denisse
AU - Viola, Lucia
AU - Del Re, Marzia
AU - Russo, Alessandro
AU - de Miguel-Perez, Diego
AU - Cardona, Andrés F.
AU - Rolfo, Christian
N1 - Publisher Copyright:
© 2024 Elsevier B.V.
PY - 2024/10
Y1 - 2024/10
N2 - Lung cancer (LC) is the leading cause of cancer-related deaths worldwide and the second most common cancer in both men and women. In addition to smoking, other risk factors, such as environmental tobacco smoke, air pollution, biomass combustion, radon gas, occupational exposure, lung disease, family history of cancer, geographic variability, and genetic factors, play an essential role in developing LC. Current screening guidelines and eligibility criteria have limited efficacy in identifying LC cases (50 %), as most screening programs primarily target subjects with a smoking history as the leading risk factor. Implementing LC screening programs in people who have never smoked (PNS) can significantly impact cancer-specific survival and early disease detection. However, the available evidence regarding the feasibility and effectiveness of such programs is limited. Therefore, further research on LC screening in PNS is warranted to determine the necessary techniques for accurately identifying individuals who should be included in screening programs.
AB - Lung cancer (LC) is the leading cause of cancer-related deaths worldwide and the second most common cancer in both men and women. In addition to smoking, other risk factors, such as environmental tobacco smoke, air pollution, biomass combustion, radon gas, occupational exposure, lung disease, family history of cancer, geographic variability, and genetic factors, play an essential role in developing LC. Current screening guidelines and eligibility criteria have limited efficacy in identifying LC cases (50 %), as most screening programs primarily target subjects with a smoking history as the leading risk factor. Implementing LC screening programs in people who have never smoked (PNS) can significantly impact cancer-specific survival and early disease detection. However, the available evidence regarding the feasibility and effectiveness of such programs is limited. Therefore, further research on LC screening in PNS is warranted to determine the necessary techniques for accurately identifying individuals who should be included in screening programs.
KW - Cancer early detection
KW - Low dose CT scan
KW - Lung cancer screening
KW - Lung neoplasm
KW - Never smokers
UR - http://www.scopus.com/inward/record.url?scp=85199337564&partnerID=8YFLogxK
U2 - 10.1016/j.critrevonc.2024.104436
DO - 10.1016/j.critrevonc.2024.104436
M3 - Review article
C2 - 38977146
AN - SCOPUS:85199337564
SN - 1040-8428
VL - 202
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
M1 - 104436
ER -