Facile synthesis of (±)-paeonilide

Yuguo Du; Jun Liu; Robert J. Linhardt

doi:10.1021/jo0701278

Facile synthesis of (±)-paeonilide

Yuguo Du
, Jun Liu
, Robert J. Linhardt

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

(Chemical Equation Presented) (±)-Paeonilide, a novel monoterpenoid metabolite from the roots of Paeonia delavayi showing anti-platelet activating factor activity, is convergently synthesized in five steps with 59% overall yield. The application of benzoyl peroxide-promoted radical addition of unsaturated ester to aldehyde and subsequent topologically favored cyclization greatly simplified the synthesis.

Original language	English
Pages (from-to)	3952-3954
Number of pages	3
Journal	Journal of Organic Chemistry
Volume	72
Issue number	10
DOIs	https://doi.org/10.1021/jo0701278
State	Published - 11 May 2007
Externally published	Yes

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@article{f47c12fcbede4792a6df8070498a6254,

title = "Facile synthesis of (±)-paeonilide",

abstract = "(Chemical Equation Presented) (±)-Paeonilide, a novel monoterpenoid metabolite from the roots of Paeonia delavayi showing anti-platelet activating factor activity, is convergently synthesized in five steps with 59\% overall yield. The application of benzoyl peroxide-promoted radical addition of unsaturated ester to aldehyde and subsequent topologically favored cyclization greatly simplified the synthesis.",

author = "Yuguo Du and Jun Liu and Linhardt, \{Robert J.\}",

year = "2007",

month = may,

day = "11",

doi = "10.1021/jo0701278",

language = "English",

volume = "72",

pages = "3952--3954",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society",

number = "10",

}

TY - JOUR

T1 - Facile synthesis of (±)-paeonilide

AU - Du, Yuguo

AU - Liu, Jun

AU - Linhardt, Robert J.

PY - 2007/5/11

Y1 - 2007/5/11

N2 - (Chemical Equation Presented) (±)-Paeonilide, a novel monoterpenoid metabolite from the roots of Paeonia delavayi showing anti-platelet activating factor activity, is convergently synthesized in five steps with 59% overall yield. The application of benzoyl peroxide-promoted radical addition of unsaturated ester to aldehyde and subsequent topologically favored cyclization greatly simplified the synthesis.

AB - (Chemical Equation Presented) (±)-Paeonilide, a novel monoterpenoid metabolite from the roots of Paeonia delavayi showing anti-platelet activating factor activity, is convergently synthesized in five steps with 59% overall yield. The application of benzoyl peroxide-promoted radical addition of unsaturated ester to aldehyde and subsequent topologically favored cyclization greatly simplified the synthesis.

UR - https://www.scopus.com/pages/publications/34248584010

U2 - 10.1021/jo0701278

DO - 10.1021/jo0701278

M3 - Article

C2 - 17411097

AN - SCOPUS:34248584010

SN - 0022-3263

VL - 72

SP - 3952

EP - 3954

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 10

ER -

Facile synthesis of (±)-paeonilide

Abstract

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