Abstract
Novel analogs of SGLT2 inhibitors containing the 1,2,3-triazole motif were designed and synthesized for urinary glucose excretion evaluation. The C-glucosides with triazole aglycone can be easily constructed by click chemistry. Most of the synthesized compounds increased urinary glucose excretion and demonstrated inhibition of glucose transport.
Original language | English |
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Pages (from-to) | 642-644 |
Number of pages | 3 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 22 |
Issue number | 1 |
DOIs | |
State | Published - 1 Jan 2012 |
Externally published | Yes |
Keywords
- Click chemistry
- Diabetes
- Metabolic diseases
- SGLT2
- Triazole