Facile synthesis of 1,2,3-triazole analogs of SGLT2 inhibitors by 'click chemistry'

Lan Tao Li, Li Fei Zhou, Yan Jun Li, Juan Huang, Rui Hua Liu, Bin Wang, Peng Wang

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Novel analogs of SGLT2 inhibitors containing the 1,2,3-triazole motif were designed and synthesized for urinary glucose excretion evaluation. The C-glucosides with triazole aglycone can be easily constructed by click chemistry. Most of the synthesized compounds increased urinary glucose excretion and demonstrated inhibition of glucose transport.

Original languageEnglish
Pages (from-to)642-644
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Issue number1
StatePublished - 1 Jan 2012
Externally publishedYes


  • Click chemistry
  • Diabetes
  • Metabolic diseases
  • SGLT2
  • Triazole


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