@article{7942de898ccb44769bfb79f1a3b69341,
title = "FaceBase 3: Analytical tools and FAIR resources for craniofacial and dental research",
abstract = "The FaceBase Consortium was established by the National Institute of Dental and Craniofacial Research in 2009 as a 'big data' resource for the craniofacial research community. Over the past decade, researchers have deposited hundreds of annotated and curated datasets on both normal and disordered craniofacial development in FaceBase, all freely available to the research community on the FaceBase Hub website. The Hub has developed numerous visualization and analysis tools designed to promote integration of multidisciplinary data while remaining dedicated to the FAIR principles of data management (findability, accessibility, interoperability and reusability) and providing a faceted search infrastructure for locating desired data efficiently. Summaries of the datasets generated by the FaceBase projects from 2014 to 2019 are provided here. FaceBase 3 now welcomes contributions of data on craniofacial and dental development in humans, model organisms and cell lines. Collectively, the FaceBase Consortium, along with other NIH-supported data resources, provide a continuously growing, dynamic and current resource for the scientific community while improving data reproducibility and fulfilling data sharing requirements.",
keywords = "Craniofacial development, Data resource, FaceBase Consortium, Human, Mouse, Zebrafish",
author = "Samuels, {Bridget D.} and Robert Aho and Brinkley, {James F.} and Alejandro Bugacov and Eleanor Feingold and Shannon Fisher and Gonzalez-Reiche, {Ana S.} and Hacia, {Joseph G.} and Benedikt Hallgrimsson and Karissa Hansen and Harris, {Matthew P.} and Ho, {Thach Vu} and Greg Holmes and Hooper, {Joan E.} and Jabs, {Ethylin Wang} and Jones, {Kenneth L.} and Carl Kesselman and Klein, {Ophir D.} and Leslie, {Elizabeth J.} and Hong Li and Liao, {Eric C.} and Hannah Long and Na Lu and Maas, {Richard L.} and Marazita, {Mary L.} and Jaaved Mohammed and Sara Prescott and Robert Schuler and Licia Selleri and Spritz, {Richard A.} and Tomek Swigut and {van Bakel}, Harm and Axel Visel and Ian Welsh and Cristina Williams and Williams, {Trevor J.} and Joanna Wysocka and Yuan Yuan and Yang Chai",
note = "Funding Information: Over the past decade, the biomedical fields have witnessed tremendous growth and technological advancement, driven in part by the exponential growth of {\textquoteleft}big data{\textquoteright} assets and the computational resources necessary to unlock their potential. The FaceBase Consortium, funded by the National Institute of Dental and Craniofacial Research (NIDCR) of the National Institutes of Health (NIH), was established in 2009 with the goal of enabling the craniofacial research community to share in this data revolution. FaceBase seeks to provide a comprehensive, trustworthy data repository that integrates innovative analysis and visualization tools with educational resources on craniofacial development. All aspects of FaceBase have been designed with the FAIR (findability, accessibility, interoperability and reusability) data principles in mind (Wilkinson et al., 2016). FaceBase promotes multidisciplinary collaboration and research in craniofacial development, molecular genetics and genomics by providing a platform for researchers to analyze, integrate and annotate datasets before and after they are published. The curated content available through FaceBase empowers the research community to leverage the tremendous resources developed by laboratories worldwide to accelerate their own hypothesis-driven basic, translational and clinical research. Now, FaceBase is opening its doors to researchers who wish to make their datasets accessible through the Hub and take advantage of the toolkit it provides for analyzing, visualizing and integrating numerous data types. Funding Information: The FaceBase 3 Hub is supported by the National Institute of Dental and Craniofacial Research (U01-DE028729 to C.K. and Y.C.). The FaceBase 2 Consortium projects were supported by the following awards from the National Institute of Dental and Craniofacial Research: U01-DE024449 (C.K.), U01-DE024434 (S.F. and M.P.H.), U01-DE024440 (R.S. and O.D.K.), U01-DE024430 (J.W. and L.S.), U01-DE024427 (A.V.), U01-DE024425 (M.L.M.), U01-DE024421 (Y.C.), U01-DE024417 (J.F.B.), U01-DE024443 (R.M.), U01-DE024429 (T.J.W., J.G.H. and K.L.J.) and U01-DE024448 (E.W.J., G.H. and H.v.B.). Research conducted at the E.O. Lawrence Berkeley National Laboratory was performed under Publisher Copyright: {\textcopyright} 2020. Published by The Company of Biologists Ltd",
year = "2020",
month = sep,
doi = "10.1242/dev.191213",
language = "English",
volume = "147",
journal = "Development (Cambridge)",
issn = "0950-1991",
publisher = "Company of Biologists Ltd",
number = "18",
}