Eye position-dependent opsoclonus in mild traumatic brain injury

John Ross Rizzo; Todd E. Hudson; Alexandra J. Sequeira; Weiwei Dai; Yash Chaudhry; John Martone; David S. Zee; Lance M. Optican; Laura J. Balcer; Steven L. Galetta; Janet C. Rucker

doi:10.1016/bs.pbr.2019.04.016

Eye position-dependent opsoclonus in mild traumatic brain injury

John Ross Rizzo
, Todd E. Hudson
, Alexandra J. Sequeira
, Weiwei Dai
, Yash Chaudhry
, John Martone
, David S. Zee
, Lance M. Optican
, Laura J. Balcer
, Steven L. Galetta
, Janet C. Rucker

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

12 Scopus citations

Abstract

Opsoclonus consists of bursts of involuntary, multidirectional, back-to-back saccades without an intersaccadic interval. We report a 60-year-old man with post-concussive headaches and disequilibrium who had small amplitude opsoclonus in left gaze, along with larger amplitude flutter during convergence. Examination was otherwise normal and brain MRI was unremarkable. Video-oculography demonstrated opsoclonus predominantly in left gaze and during pursuit in the left hemifield, which improved as post-concussive symptoms improved. Existing theories of opsoclonus mechanisms do not account for this eye position-dependence. We discuss theoretical mechanisms of this behavior, including possible dysfunction of frontal eye field and/or cerebellar vermis neurons; review ocular oscillations in traumatic brain injury; and consider the potential relationship between the larger amplitude flutter upon convergence and post-traumatic ocular oscillations.

Original language	English
Title of host publication	Mathematical Modelling in Motor Neuroscience
Subtitle of host publication	State of the Art and Translation to the Clinic. Gaze Orienting Mechanisms and Disease
Editors	Stefano Ramat, Aasef G. Shaikh
Publisher	Elsevier B.V.
Pages	65-78
Number of pages	14
ISBN (Print)	9780444642547
DOIs	https://doi.org/10.1016/bs.pbr.2019.04.016
State	Published - 2019
Externally published	Yes

Publication series

Name	Progress in Brain Research
Volume	249
ISSN (Print)	0079-6123
ISSN (Electronic)	1875-7855

Keywords

Concussion
Eye position-dependence
Ocular flutter
Opsoclonus
Saccades

Access to Document

10.1016/bs.pbr.2019.04.016

Cite this

Rizzo, J. R., Hudson, T. E., Sequeira, A. J., Dai, W., Chaudhry, Y., Martone, J., Zee, D. S., Optican, L. M., Balcer, L. J., Galetta, S. L., & Rucker, J. C. (2019). Eye position-dependent opsoclonus in mild traumatic brain injury. In S. Ramat, & A. G. Shaikh (Eds.), Mathematical Modelling in Motor Neuroscience: State of the Art and Translation to the Clinic. Gaze Orienting Mechanisms and Disease (pp. 65-78). (Progress in Brain Research; Vol. 249). Elsevier B.V.. https://doi.org/10.1016/bs.pbr.2019.04.016

Rizzo, John Ross ; Hudson, Todd E. ; Sequeira, Alexandra J. et al. / Eye position-dependent opsoclonus in mild traumatic brain injury. Mathematical Modelling in Motor Neuroscience: State of the Art and Translation to the Clinic. Gaze Orienting Mechanisms and Disease. editor / Stefano Ramat ; Aasef G. Shaikh. Elsevier B.V., 2019. pp. 65-78 (Progress in Brain Research).

@inbook{38eb35a9ed8e4e598727df25983dfc94,

title = "Eye position-dependent opsoclonus in mild traumatic brain injury",

abstract = "Opsoclonus consists of bursts of involuntary, multidirectional, back-to-back saccades without an intersaccadic interval. We report a 60-year-old man with post-concussive headaches and disequilibrium who had small amplitude opsoclonus in left gaze, along with larger amplitude flutter during convergence. Examination was otherwise normal and brain MRI was unremarkable. Video-oculography demonstrated opsoclonus predominantly in left gaze and during pursuit in the left hemifield, which improved as post-concussive symptoms improved. Existing theories of opsoclonus mechanisms do not account for this eye position-dependence. We discuss theoretical mechanisms of this behavior, including possible dysfunction of frontal eye field and/or cerebellar vermis neurons; review ocular oscillations in traumatic brain injury; and consider the potential relationship between the larger amplitude flutter upon convergence and post-traumatic ocular oscillations.",

keywords = "Concussion, Eye position-dependence, Ocular flutter, Opsoclonus, Saccades",

author = "Rizzo, \{John Ross\} and Hudson, \{Todd E.\} and Sequeira, \{Alexandra J.\} and Weiwei Dai and Yash Chaudhry and John Martone and Zee, \{David S.\} and Optican, \{Lance M.\} and Balcer, \{Laura J.\} and Galetta, \{Steven L.\} and Rucker, \{Janet C.\}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

year = "2019",

doi = "10.1016/bs.pbr.2019.04.016",

language = "English",

isbn = "9780444642547",

series = "Progress in Brain Research",

publisher = "Elsevier B.V.",

pages = "65--78",

editor = "Stefano Ramat and Shaikh, \{Aasef G.\}",

booktitle = "Mathematical Modelling in Motor Neuroscience",

}

Rizzo, JR, Hudson, TE, Sequeira, AJ, Dai, W, Chaudhry, Y, Martone, J, Zee, DS, Optican, LM, Balcer, LJ, Galetta, SL & Rucker, JC 2019, Eye position-dependent opsoclonus in mild traumatic brain injury. in S Ramat & AG Shaikh (eds), Mathematical Modelling in Motor Neuroscience: State of the Art and Translation to the Clinic. Gaze Orienting Mechanisms and Disease. Progress in Brain Research, vol. 249, Elsevier B.V., pp. 65-78. https://doi.org/10.1016/bs.pbr.2019.04.016

Eye position-dependent opsoclonus in mild traumatic brain injury. / Rizzo, John Ross; Hudson, Todd E.; Sequeira, Alexandra J. et al.
Mathematical Modelling in Motor Neuroscience: State of the Art and Translation to the Clinic. Gaze Orienting Mechanisms and Disease. ed. / Stefano Ramat; Aasef G. Shaikh. Elsevier B.V., 2019. p. 65-78 (Progress in Brain Research; Vol. 249).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

TY - CHAP

T1 - Eye position-dependent opsoclonus in mild traumatic brain injury

AU - Rizzo, John Ross

AU - Hudson, Todd E.

AU - Sequeira, Alexandra J.

AU - Dai, Weiwei

AU - Chaudhry, Yash

AU - Martone, John

AU - Zee, David S.

AU - Optican, Lance M.

AU - Balcer, Laura J.

AU - Galetta, Steven L.

AU - Rucker, Janet C.

PY - 2019

Y1 - 2019

N2 - Opsoclonus consists of bursts of involuntary, multidirectional, back-to-back saccades without an intersaccadic interval. We report a 60-year-old man with post-concussive headaches and disequilibrium who had small amplitude opsoclonus in left gaze, along with larger amplitude flutter during convergence. Examination was otherwise normal and brain MRI was unremarkable. Video-oculography demonstrated opsoclonus predominantly in left gaze and during pursuit in the left hemifield, which improved as post-concussive symptoms improved. Existing theories of opsoclonus mechanisms do not account for this eye position-dependence. We discuss theoretical mechanisms of this behavior, including possible dysfunction of frontal eye field and/or cerebellar vermis neurons; review ocular oscillations in traumatic brain injury; and consider the potential relationship between the larger amplitude flutter upon convergence and post-traumatic ocular oscillations.

AB - Opsoclonus consists of bursts of involuntary, multidirectional, back-to-back saccades without an intersaccadic interval. We report a 60-year-old man with post-concussive headaches and disequilibrium who had small amplitude opsoclonus in left gaze, along with larger amplitude flutter during convergence. Examination was otherwise normal and brain MRI was unremarkable. Video-oculography demonstrated opsoclonus predominantly in left gaze and during pursuit in the left hemifield, which improved as post-concussive symptoms improved. Existing theories of opsoclonus mechanisms do not account for this eye position-dependence. We discuss theoretical mechanisms of this behavior, including possible dysfunction of frontal eye field and/or cerebellar vermis neurons; review ocular oscillations in traumatic brain injury; and consider the potential relationship between the larger amplitude flutter upon convergence and post-traumatic ocular oscillations.

KW - Concussion

KW - Eye position-dependence

KW - Ocular flutter

KW - Opsoclonus

KW - Saccades

UR - https://www.scopus.com/pages/publications/85065845342

U2 - 10.1016/bs.pbr.2019.04.016

DO - 10.1016/bs.pbr.2019.04.016

M3 - Chapter

C2 - 31325998

AN - SCOPUS:85065845342

SN - 9780444642547

T3 - Progress in Brain Research

SP - 65

EP - 78

BT - Mathematical Modelling in Motor Neuroscience

A2 - Ramat, Stefano

A2 - Shaikh, Aasef G.

PB - Elsevier B.V.

ER -

Rizzo JR, Hudson TE, Sequeira AJ, Dai W, Chaudhry Y, Martone J et al. Eye position-dependent opsoclonus in mild traumatic brain injury. In Ramat S, Shaikh AG, editors, Mathematical Modelling in Motor Neuroscience: State of the Art and Translation to the Clinic. Gaze Orienting Mechanisms and Disease. Elsevier B.V. 2019. p. 65-78. (Progress in Brain Research). doi: 10.1016/bs.pbr.2019.04.016

Eye position-dependent opsoclonus in mild traumatic brain injury

Abstract

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Keywords

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