EYA1-SIX1 complex in neurosensory cell fate induction in the mammalian inner ear

Elaine Y.M. Wong; Mohi Ahmed; Pin Xian Xu

doi:10.1016/j.heares.2012.09.009

EYA1-SIX1 complex in neurosensory cell fate induction in the mammalian inner ear

Elaine Y.M. Wong, Mohi Ahmed, Pin Xian Xu

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Abstract

The phosphatase-transactivator EYA1 interacts with the homeodomain protein SIX1 to form transcriptional activation complexes, which play essential roles in regulating cell proliferation, survival and induction of sensory and neuronal differentiation programs during inner ear development. Mutations of the Eya1 and Six1 genes cause profound developmental auditory defects in mice and humans. The molecular mechanisms and developmental processes controlled by the EYA1 and SIX1 complex in inner ear development and neurosensory fate induction are the focus of this review.

Original language	English
Pages (from-to)	13-19
Number of pages	7
Journal	Hearing Research
Volume	297
DOIs	https://doi.org/10.1016/j.heares.2012.09.009
State	Published - Mar 2013

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title = "EYA1-SIX1 complex in neurosensory cell fate induction in the mammalian inner ear",

abstract = "The phosphatase-transactivator EYA1 interacts with the homeodomain protein SIX1 to form transcriptional activation complexes, which play essential roles in regulating cell proliferation, survival and induction of sensory and neuronal differentiation programs during inner ear development. Mutations of the Eya1 and Six1 genes cause profound developmental auditory defects in mice and humans. The molecular mechanisms and developmental processes controlled by the EYA1 and SIX1 complex in inner ear development and neurosensory fate induction are the focus of this review.",

author = "Wong, {Elaine Y.M.} and Mohi Ahmed and Xu, {Pin Xian}",

note = "Funding Information: The authors wish to thank all of the past and present members of our lab for their many contributions and valuable discussions. Some of the work presented was supported by the NIH grant RO1 DC005824 (P-X. X.).",

year = "2013",

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doi = "10.1016/j.heares.2012.09.009",

language = "English",

volume = "297",

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T1 - EYA1-SIX1 complex in neurosensory cell fate induction in the mammalian inner ear

AU - Wong, Elaine Y.M.

AU - Ahmed, Mohi

AU - Xu, Pin Xian

N1 - Funding Information: The authors wish to thank all of the past and present members of our lab for their many contributions and valuable discussions. Some of the work presented was supported by the NIH grant RO1 DC005824 (P-X. X.).

PY - 2013/3

Y1 - 2013/3

N2 - The phosphatase-transactivator EYA1 interacts with the homeodomain protein SIX1 to form transcriptional activation complexes, which play essential roles in regulating cell proliferation, survival and induction of sensory and neuronal differentiation programs during inner ear development. Mutations of the Eya1 and Six1 genes cause profound developmental auditory defects in mice and humans. The molecular mechanisms and developmental processes controlled by the EYA1 and SIX1 complex in inner ear development and neurosensory fate induction are the focus of this review.

AB - The phosphatase-transactivator EYA1 interacts with the homeodomain protein SIX1 to form transcriptional activation complexes, which play essential roles in regulating cell proliferation, survival and induction of sensory and neuronal differentiation programs during inner ear development. Mutations of the Eya1 and Six1 genes cause profound developmental auditory defects in mice and humans. The molecular mechanisms and developmental processes controlled by the EYA1 and SIX1 complex in inner ear development and neurosensory fate induction are the focus of this review.

UR - http://www.scopus.com/inward/record.url?scp=84875380020&partnerID=8YFLogxK

U2 - 10.1016/j.heares.2012.09.009

DO - 10.1016/j.heares.2012.09.009

M3 - Review article

C2 - 23104013

AN - SCOPUS:84875380020

SN - 0378-5955

VL - 297

SP - 13

EP - 19

JO - Hearing Research

JF - Hearing Research

ER -

EYA1-SIX1 complex in neurosensory cell fate induction in the mammalian inner ear

Abstract

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