TY - JOUR
T1 - Extrajunctional Acetylcholine Receptors
T2 - Alterations in Human and Experimental Neuromuscular Diseases
AU - Ringel, Steven P.
AU - Bender, Adam N.
AU - Engel, W. King
PY - 1976/11
Y1 - 1976/11
N2 - Diffuse extrajunctional acetylcholine receptors (AChR) of skeletal muscle fibers were readily visualized by light and electron microscopy in muscle biopsy specimens of experimental denervation and human denervating diseases by use of an α-bungarotoxin immunoperoxidase technique. In peripheral neuropathies and various motor neuron diseases, a significant number of muscle fibers appearing denervated by histochemical criteria have diffuse extrajunctional AChR like those experimentally denervated by cutting the motor nerve supply. In portions of muscle fibers experimentally deprived of neuronal influence by direct injury, diffuse extrajunctional AChR developed, demonstrating that a denervation-like diffuse appearance of extrajunctional AChR can develop other than with neuronal damage, ie, it can be myogenous. Similar extrajunctional AChR was seen in some regenerating fibers of human myopathies, especially inflammatory myopathies.
AB - Diffuse extrajunctional acetylcholine receptors (AChR) of skeletal muscle fibers were readily visualized by light and electron microscopy in muscle biopsy specimens of experimental denervation and human denervating diseases by use of an α-bungarotoxin immunoperoxidase technique. In peripheral neuropathies and various motor neuron diseases, a significant number of muscle fibers appearing denervated by histochemical criteria have diffuse extrajunctional AChR like those experimentally denervated by cutting the motor nerve supply. In portions of muscle fibers experimentally deprived of neuronal influence by direct injury, diffuse extrajunctional AChR developed, demonstrating that a denervation-like diffuse appearance of extrajunctional AChR can develop other than with neuronal damage, ie, it can be myogenous. Similar extrajunctional AChR was seen in some regenerating fibers of human myopathies, especially inflammatory myopathies.
UR - http://www.scopus.com/inward/record.url?scp=0017096564&partnerID=8YFLogxK
U2 - 10.1001/archneur.1976.00500110019004
DO - 10.1001/archneur.1976.00500110019004
M3 - Article
C2 - 185992
AN - SCOPUS:0017096564
SN - 0003-9942
VL - 33
SP - 751
EP - 758
JO - Archives of Neurology
JF - Archives of Neurology
IS - 11
ER -