Extracorporeal Therapies in Acute Intoxication and Poisoning

Nikolas Harbord, James Frank Winchester, Elliot Charen, Naitik Sheth, Arjun Bhansali

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Scopus citations


The chapter provides an overview of the management of the poisoned patient and introduces extracorporeal therapies to aid in detoxification. Indications for the use of hemodialysis, hemofiltration, and hemoperfusion are reviewed, and the principles underlying drug removal with each modality are described. Additional consideration is given to addition of chelating agents to augment clearance of metals, such as aluminum and iron. Clinical presentation, diagnosis, and therapeutic approach including extracorporeal treatment are described in detail for specific intoxicants: lithium, methanol, ethylene glycol, and salicylates. Comprehensive tables are included, containing drugs and intoxicants removed with extracorporeal therapy.

Original languageEnglish
Title of host publicationCritical Care Nephrology
Subtitle of host publicationThird Edition
PublisherElsevier Inc.
ISBN (Electronic)9780323449427
ISBN (Print)9780323449427
StatePublished - 2019


  • Chelation
  • Ethylene glycol
  • Hemodialysis
  • Hemofiltration
  • Hemoperfusion
  • Intoxication
  • Lithium
  • Methanol
  • Poisoning
  • Salicylates
  • Theophylline


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