Extracorporeal photopheresis reverses experimental graft-versus-host disease through regulatory T cells

Erin Gatza, Clare E. Rogers, Shawn G. Clouthier, Kathleen P. Lowler, Isao Tawara, Chen Liu, Pavan Reddy, James L.M. Ferrara

Research output: Contribution to journalArticlepeer-review

180 Scopus citations


Extracorporeal photopheresis (ECP), a technique that exposes isolated white blood cells to photoactivatable 8-methoxypsoralen and ultraviolet A radiation, is used clinically to treat cutaneous T-cell lymphoma and immune-mediated diseases such as graft-versus-host disease (GVHD). ECP is thought to control these diseases in part through direct induction of lymphocyte apoptosis, but its effects on the immune system beyond apoptosis remain poorly characterized. We have developed a novel method for incorporating ECP treatment into well-established and clinically relevant murine models of GVHD to examine its effects during an ongoing immune response. We demonstrate that the transfer of cells treated with ECP reverses established GVHD by increasing donor regulatory T cells and indirectly reducing the number of donor effector lymphocytes that themselves had never been exposed to psoralen and ultraviolet A radiation.

Original languageEnglish
Pages (from-to)1515-1521
Number of pages7
Issue number4
StatePublished - 15 Aug 2008
Externally publishedYes


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