TY - JOUR
T1 - Extracorporeal Membrane Oxygenation for Massive Pulmonary Thromboembolism
AU - Krellenstein, Daniel J.
AU - Bryan-Brown, Christopher W.
AU - Fayemi, A. Olusegun
AU - Geller, Stephen A.
AU - Hanns, Jennifer
AU - Barron, Susan
AU - Peirce, E. Converse
N1 - Funding Information:
From the Department of Surgery, Veterans Administration Hospital, Bronx, and the Departments of Surgery and Pathology, Mount Sinai School of Medicine of the City University of New York, New York, NY. Supported by Veterans Administration Project 7240-06 and National Heart and Lung Institute Contract N01-HR-42923. Accepted for publication Sept 27, 1976.
PY - 1977
Y1 - 1977
N2 - This study was undertaken to determine whether extracorporeal membrane oxygenation (ECMO) could modify the effects of massive lethal thromboembolism and prevent death. Twenty anesthetized dogs were prepared for venoarterial perfusion with a demand pump and membrane lung and were perfused slowly for 1 1/2 hours to lessen homologous blood shock; 1 ml per kilogram of 24-hour-old tantalum-impregnated thrombus was injected intravenously. The dogs had profound systemic hypotension with an elevated mean pulmonary artery pressure (62.9 ± 4.5 mm Hg) immediately after embolization. Control animals generally died within 15 minutes. Four of the 10 ECMO-supported animals lived for six days, at which time they were restudied and killed. Not only can ECMO maintain an animal that would otherwise die quickly of massive pulmonary thromboembolism, but such support, even though temporary, can greatly improve the chances of survival.
AB - This study was undertaken to determine whether extracorporeal membrane oxygenation (ECMO) could modify the effects of massive lethal thromboembolism and prevent death. Twenty anesthetized dogs were prepared for venoarterial perfusion with a demand pump and membrane lung and were perfused slowly for 1 1/2 hours to lessen homologous blood shock; 1 ml per kilogram of 24-hour-old tantalum-impregnated thrombus was injected intravenously. The dogs had profound systemic hypotension with an elevated mean pulmonary artery pressure (62.9 ± 4.5 mm Hg) immediately after embolization. Control animals generally died within 15 minutes. Four of the 10 ECMO-supported animals lived for six days, at which time they were restudied and killed. Not only can ECMO maintain an animal that would otherwise die quickly of massive pulmonary thromboembolism, but such support, even though temporary, can greatly improve the chances of survival.
UR - http://www.scopus.com/inward/record.url?scp=0017332502&partnerID=8YFLogxK
U2 - 10.1016/S0003-4975(10)64161-6
DO - 10.1016/S0003-4975(10)64161-6
M3 - Article
AN - SCOPUS:0017332502
SN - 0003-4975
VL - 23
SP - 421
EP - 428
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
IS - 5
ER -