Extracellular regulation of transforming growth factor β and bone morphogenetic protein signaling in bone

Harikiran Nistala, Sui Lee-Arteaga, Gabriella Siciliano, Silvia Smaldone, Francesco Ramirez

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

26 Scopus citations


Systemic and local factors regulate the activity of osteoblasts and osteoclasts during bone growth and remodeling by modulating a complex array of intracellular signaling events. Recent genetic evidence implicates extracellular fibrillin assemblies (microfibrils and elastic fibers) in imparting contextual specificity to endogenous transforming growth factor-β and bone morphogenetic protein ligands in the forming and mature skeleton. The evidence is based on the characterization of the cellular and molecular mechanisms responsible for the unique bone manifestations that characterize mouse models of Marfan syndrome and congenital contractural arachnodactyly. Collectively, the studies indicate that fibrillin assemblies play a key role both in establishing morphogen gradients within the developing limbs and in restricting growth factors activity in remodeling bones. The latter finding is likely to improve the design of more effective therapeutic interventions in osteoporosis and of bioengineering formulations for the repair of bone fractures.

Original languageEnglish
Title of host publicationSkeletal Biology and Medicine
PublisherBlackwell Publishing Inc.
Number of pages4
ISBN (Print)9781573317856
StatePublished - Mar 2010

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632


  • BMP
  • Fibrillin microfibrils
  • Marfan syndrome
  • Osteoblast differentiation
  • Osteopenia
  • TGF-β


Dive into the research topics of 'Extracellular regulation of transforming growth factor β and bone morphogenetic protein signaling in bone'. Together they form a unique fingerprint.

Cite this