Extracellular Matrix in Ischemic Heart Disease, Part 4/4: JACC Focus Seminar

Nikolaos G. Frangogiannis, Jason C. Kovacic

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations


Myocardial ischemia and infarction, both in the acute and chronic phases, are associated with cardiomyocyte loss and dramatic changes in the cardiac extracellular matrix (ECM). It has long been appreciated that these changes in the cardiac ECM result in altered mechanical properties of ischemic or infarcted myocardial segments. However, a growing body of evidence now clearly demonstrates that these alterations of the ECM not only affect the structural properties of the ischemic and post-infarct heart, but they also play a crucial and sometimes direct role in mediating a range of biological pathways, including the orchestration of inflammatory and reparative processes, as well as the pathogenesis of adverse remodeling. This final part of a 4-part JACC Focus Seminar reviews the evidence on the role of the ECM in relation to the ischemic and infarcted heart, as well as its contribution to cardiac dysfunction and adverse clinical outcomes.

Original languageEnglish
Pages (from-to)2219-2235
Number of pages17
JournalJournal of the American College of Cardiology
Issue number17
StatePublished - 5 May 2020


  • biomarker
  • collagen
  • fibroblast
  • heart failure
  • ischemic heart disease


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