Extracellular Matrix Enzymes and Immune Cell Biology

Meagan McMahon, Siying Ye, Jess Pedrina, Daniel Dlugolenski, John Stambas

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

Remodelling of the extracellular matrix (ECM) by ECM metalloproteinases is increasingly being associated with regulation of immune cell function. ECM metalloproteinases, including Matrix Metalloproteinases (MMPs), A Disintegrin and Metalloproteinases (ADAMs) and ADAMs with Thombospondin-1 motifs (ADAMTS) play a vital role in pathogen defence and have been shown to influence migration of immune cells. This review provides a current summary of the role of ECM enzymes in immune cell migration and function and discusses opportunities and limitations for development of diagnostic and therapeutic strategies targeting metalloproteinase expression and activity in the context of infectious disease.

Original languageEnglish
Article number703868
JournalFrontiers in Molecular Biosciences
Volume8
DOIs
StatePublished - 30 Aug 2021
Externally publishedYes

Keywords

  • a disintegrin and metalloproteinases
  • a disintegrin and metalloproteinases with thombospondin-1 motifs
  • extracellular matrix
  • immunity
  • metalloproteinases

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