Extracellular Matrix Enzymes and Immune Cell Biology

Meagan McMahon; Siying Ye; Jess Pedrina; Daniel Dlugolenski; John Stambas

doi:10.3389/fmolb.2021.703868

Extracellular Matrix Enzymes and Immune Cell Biology

Meagan McMahon, Siying Ye, Jess Pedrina, Daniel Dlugolenski, John Stambas

Research output: Contribution to journal › Review article › peer-review

36 Scopus citations

Abstract

Remodelling of the extracellular matrix (ECM) by ECM metalloproteinases is increasingly being associated with regulation of immune cell function. ECM metalloproteinases, including Matrix Metalloproteinases (MMPs), A Disintegrin and Metalloproteinases (ADAMs) and ADAMs with Thombospondin-1 motifs (ADAMTS) play a vital role in pathogen defence and have been shown to influence migration of immune cells. This review provides a current summary of the role of ECM enzymes in immune cell migration and function and discusses opportunities and limitations for development of diagnostic and therapeutic strategies targeting metalloproteinase expression and activity in the context of infectious disease.

Original language	English
Article number	703868
Journal	Frontiers in Molecular Biosciences
Volume	8
DOIs	https://doi.org/10.3389/fmolb.2021.703868
State	Published - 30 Aug 2021
Externally published	Yes

Keywords

a disintegrin and metalloproteinases
a disintegrin and metalloproteinases with thombospondin-1 motifs
extracellular matrix
immunity
metalloproteinases

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title = "Extracellular Matrix Enzymes and Immune Cell Biology",

abstract = "Remodelling of the extracellular matrix (ECM) by ECM metalloproteinases is increasingly being associated with regulation of immune cell function. ECM metalloproteinases, including Matrix Metalloproteinases (MMPs), A Disintegrin and Metalloproteinases (ADAMs) and ADAMs with Thombospondin-1 motifs (ADAMTS) play a vital role in pathogen defence and have been shown to influence migration of immune cells. This review provides a current summary of the role of ECM enzymes in immune cell migration and function and discusses opportunities and limitations for development of diagnostic and therapeutic strategies targeting metalloproteinase expression and activity in the context of infectious disease.",

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AU - McMahon, Meagan

AU - Ye, Siying

AU - Pedrina, Jess

AU - Dlugolenski, Daniel

AU - Stambas, John

PY - 2021/8/30

Y1 - 2021/8/30

N2 - Remodelling of the extracellular matrix (ECM) by ECM metalloproteinases is increasingly being associated with regulation of immune cell function. ECM metalloproteinases, including Matrix Metalloproteinases (MMPs), A Disintegrin and Metalloproteinases (ADAMs) and ADAMs with Thombospondin-1 motifs (ADAMTS) play a vital role in pathogen defence and have been shown to influence migration of immune cells. This review provides a current summary of the role of ECM enzymes in immune cell migration and function and discusses opportunities and limitations for development of diagnostic and therapeutic strategies targeting metalloproteinase expression and activity in the context of infectious disease.

AB - Remodelling of the extracellular matrix (ECM) by ECM metalloproteinases is increasingly being associated with regulation of immune cell function. ECM metalloproteinases, including Matrix Metalloproteinases (MMPs), A Disintegrin and Metalloproteinases (ADAMs) and ADAMs with Thombospondin-1 motifs (ADAMTS) play a vital role in pathogen defence and have been shown to influence migration of immune cells. This review provides a current summary of the role of ECM enzymes in immune cell migration and function and discusses opportunities and limitations for development of diagnostic and therapeutic strategies targeting metalloproteinase expression and activity in the context of infectious disease.

KW - a disintegrin and metalloproteinases

KW - a disintegrin and metalloproteinases with thombospondin-1 motifs

KW - extracellular matrix

KW - immunity

KW - metalloproteinases

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U2 - 10.3389/fmolb.2021.703868

DO - 10.3389/fmolb.2021.703868

M3 - Review article

AN - SCOPUS:85114796745

SN - 2296-889X

VL - 8

JO - Frontiers in Molecular Biosciences

JF - Frontiers in Molecular Biosciences

M1 - 703868

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Extracellular Matrix Enzymes and Immune Cell Biology

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Keywords

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