External imaging of human atherosclerosis

R. S. Lees, A. M. Lees, H. W. Strauss

Research output: Contribution to journalArticlepeer-review

82 Scopus citations

Abstract

Autologous plasma low-density lipoproteins labeled with I-125 were used as a tracer to identify atherosclerotic lesions in the carotid arteries of the neck. Following intravenous injection of I-125=LDL, images were made at intervals from 6 to 36 hr with the gamma camera in three patients with known carotid disease and one control subject. The carotid lesions, confirmed by angiography, were imaged successfully in all three patients, whereas no focal LDL accumulation was visible in the carotid arteries of the control subject. The findings suggest that it may be possible to image atherosclerosis externally and thus to follow the course of the disease.

Original languageEnglish
Pages (from-to)154-156
Number of pages3
JournalJournal of Nuclear Medicine
Volume24
Issue number2
StatePublished - 1983
Externally publishedYes

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