Extensive thoracic aortic calcification is an independent predictor of development of coronary artery calcium among individuals with coronary artery calcium score of zero

Objectives: The predictive value of thoracic aortic calcium (TAC) scores for coronary artery calcium (CAC) conversion (CAC > 0) has not been fully evaluated. Methods: We studied 1648 asymptomatic subjects (mean age 52±9 years, 54% male) with baseline CAC=0 who underwent repeat CAC scanning 5 years later (range 3-14 years). TAC was assessed in the ascending and descending aorta. CAC and TAC were measured using Agatston scores. The cohort was categorized by baseline TAC scores: TAC=0 (. n=1381 subjects), TAC 1-9 (. n=54), TAC 10-99 (. n=132) and TAC ≥ 100 (. n=81). Logistic regression was used to examine the predictive value of baseline TAC scores for CAC > 0 on repeat scans. Results: On repeat scanning, 380 subjects (23%) developed CAC > 0. The frequency of CAC > 0 increased progressively across baseline TAC (TAC=0, TAC 1-9, TAC 10-99 and TAC ≥ 100) 22%, 26%, 26% and 37%, respectively (. P for trend=0.0025). Univariate analysis showed baseline TAC ≥100 was a significant predictor of CAC > 0 in repeat scans, while either TAC 1-9 or TAC 10-99 were not, OR 2.10 [CI 1.32-3.36], P=0.002; OR 1.25 [CI 0.67-2.33], P=0.5; OR 1.24 [CI 0.82-1.87], P=0.3, respectively. In multivariable analysis, TAC ≥100 OR 1.90 [CI 1.08-3.33], P=0.026, was a significant predictor of CAC > 0, along with age, male gender, diabetes, hypertension, hypercholesterolemia and time between scans. Conclusions: The likelihood of conversion to CAC > 0 increases with increasing TAC scores. TAC ≥ 100 is an independent predictor of CAC conversion. Subjects with CAC=0 and extensive TAC (TAC ≥ 100) may merit earlier repeat scanning than those with no TAC or lower TAC scores.