Expression of p68 protein kinase as recognized by the monoclonal antibody TJ4C4 during human fetal development

G. K. Haines, G. Ghadge, J. A. Radosevich

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

In this report we describe the expression of p68, which is believed to be an important regulator of protein synthesis, in various tissues during normal human fetal development. Conventional, formalin-fixed paraffin-embedded sections of normal organs from human fetuses ranging from 9 to 42 weeks of gestation were immunostained with the monoclonal antibody TJ4C4 utilizing a conventional avidin-biotin complex procedure. The expression of p68 could be detected in many cell types arising in most of the tissues examined within the time period of fetal development studied. p68 expression was most frequently seen, and most intensely expressed in respiratory epithelium, urothelium and ependyma. Expression in other tissues was more variable. These data show that there is regulated expression of p68 in a wide variety of tissues during normal fetal development which parallels the known expression of this protein in normal and neoplastic adult tissues.

Original languageEnglish
Pages (from-to)95-104
Number of pages10
JournalTumor Biology
Volume14
Issue number2
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Dive into the research topics of 'Expression of p68 protein kinase as recognized by the monoclonal antibody TJ4C4 during human fetal development'. Together they form a unique fingerprint.

Cite this