TY - JOUR
T1 - Expression of interleukin-1 and interleukin-1 receptor antagonist by human rheumatoid synovial tissue macrophages
AU - Koch, Alisa E.
AU - Kunkel, Steven L.
AU - Chensue, Steven W.
AU - Haines, G. Kenneth
AU - Strieter, Robert M.
N1 - Funding Information:
‘This work was supported in part by NIH Grants HL31693, HL35276, HL02401, and DK38149, and Multipurpose Arthritis Center AR30692. Also, funds were provided by a V.A. Merit Review, Arthritis Foundation Grant, Council on Tobacco Research Grant, and American Lung Association Grant. Dr. Strieter is a RJR Nabisco Research Scholar. This work was presented, in part, at the National American College of Rheumatology Meeting, Boston, MA, 1991.
PY - 1992/10
Y1 - 1992/10
N2 - Interleukin-1 (IL-1) has protean effects in the pathogenesis of rheumatoid arthritis (RA). These effects include production of prostaglandins and collagenase from rheumatoid fibroblasts as well as upregulation of adhesion molecule expression on these cells. IL-1 can activate monocytes and neutrophils, as well as promote the growth of fibroblasts and endothelial cells. Recently, a novel interleukin-1 receptor antagonist protein (IRAP) has been isolated, purified, cloned, and expressed, which may modulate the effects of IL-1. In this study, we present data demonstrating that macrophages isolated from human RA synovial tissues express both IL-1 and IRAP genes. In addition, RA synovial tissue macrophages and lining cells display IL-1 and IRAP antigenic expression by immunohistochemistry. In contrast, osteoarthritis synovial tissues, as compared to RA, have fewer IL-1 and IRAP-positive macrophages. Thus, the production of IL-1 balanced by IRAP may affect the joint destruction found in these diseases.
AB - Interleukin-1 (IL-1) has protean effects in the pathogenesis of rheumatoid arthritis (RA). These effects include production of prostaglandins and collagenase from rheumatoid fibroblasts as well as upregulation of adhesion molecule expression on these cells. IL-1 can activate monocytes and neutrophils, as well as promote the growth of fibroblasts and endothelial cells. Recently, a novel interleukin-1 receptor antagonist protein (IRAP) has been isolated, purified, cloned, and expressed, which may modulate the effects of IL-1. In this study, we present data demonstrating that macrophages isolated from human RA synovial tissues express both IL-1 and IRAP genes. In addition, RA synovial tissue macrophages and lining cells display IL-1 and IRAP antigenic expression by immunohistochemistry. In contrast, osteoarthritis synovial tissues, as compared to RA, have fewer IL-1 and IRAP-positive macrophages. Thus, the production of IL-1 balanced by IRAP may affect the joint destruction found in these diseases.
UR - http://www.scopus.com/inward/record.url?scp=0026731856&partnerID=8YFLogxK
U2 - 10.1016/0090-1229(92)90243-H
DO - 10.1016/0090-1229(92)90243-H
M3 - Article
C2 - 1395121
AN - SCOPUS:0026731856
SN - 0090-1229
VL - 65
SP - 23
EP - 29
JO - Clinical Immunology and Immunopathology
JF - Clinical Immunology and Immunopathology
IS - 1
ER -