TY - JOUR
T1 - Expression of equilibrative nucleoside transporter type 1 protein in elderly patients with schizophrenia
AU - Shan, Dan
AU - Haroutunian, Vahram
AU - Meador-Woodruff, James H.
AU - McCullumsmith, Robert E.
PY - 2012/3/7
Y1 - 2012/3/7
N2 - Alterations in glutamatergic neurotransmission are thought to be involved in several psychiatric disorders, including schizophrenia. Equilibrative nucleoside transporter type 1 (ENT1) regulates glutamate levels by regulating excitatory amino acid transporter expression and activity in the brain. In this study, we investigated whether ENT1 is abnormally expressed in the brain of elderly patients with schizophrenia. We measured protein expression of ENT1 in the superior temporal gyrus (STG) and anterior cingulate cortex (ACC) in patients with schizophrenia (STG, n=22; ACC, n=34) and a comparison group (STG, n=24; ACC, n=29). We found decreased ENT1 expression in the STG in patients with schizophrenia, supporting the hypothesis of altered glutamate transport in this illness.
AB - Alterations in glutamatergic neurotransmission are thought to be involved in several psychiatric disorders, including schizophrenia. Equilibrative nucleoside transporter type 1 (ENT1) regulates glutamate levels by regulating excitatory amino acid transporter expression and activity in the brain. In this study, we investigated whether ENT1 is abnormally expressed in the brain of elderly patients with schizophrenia. We measured protein expression of ENT1 in the superior temporal gyrus (STG) and anterior cingulate cortex (ACC) in patients with schizophrenia (STG, n=22; ACC, n=34) and a comparison group (STG, n=24; ACC, n=29). We found decreased ENT1 expression in the STG in patients with schizophrenia, supporting the hypothesis of altered glutamate transport in this illness.
KW - adenosine
KW - equilibrative nucleoside transporter 1
KW - excitatory amino acid transporter
KW - glutamate
KW - schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=84857182186&partnerID=8YFLogxK
U2 - 10.1097/WNR.0b013e3283500987
DO - 10.1097/WNR.0b013e3283500987
M3 - Article
C2 - 22314683
AN - SCOPUS:84857182186
SN - 0959-4965
VL - 23
SP - 224
EP - 227
JO - NeuroReport
JF - NeuroReport
IS - 4
ER -