Expression of Bcl-2 and Bax proteins in myocardial cells after Macleaya cordata alkaloids poisoning in rats

De Yu Zhang; Qing Quan Kong; Chun Bing Zhang; Jian Hua Zhu; Ming Di Chen; Peng Wang

doi:10.3969/j.issn.1004-5619.2009.04.002

Expression of Bcl-2 and Bax proteins in myocardial cells after Macleaya cordata alkaloids poisoning in rats

De Yu Zhang, Qing Quan Kong, Chun Bing Zhang, Jian Hua Zhu, Ming Di Chen, Peng Wang

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Objective: To observe the expression of Bcl-2 and Bax proteins in rat's myocardial cells after Macleaya cordata alkaloids poisoning, and to provide certain molecular biology references for the detection of Macleaya cordata alkaloids poisoning. Methods: Experimental model of Macleaya cordata alkaloids poisoning was established, the expression levels of Bcl-2 and Bax proteins in these cells were detected by immunohistochemistry, and the results were analyzed by computer image system. Results: The expression levels of Bcl-2 and Bax proteins in myocardial cells in poisoning groups were much greater than those in the control groups (P<0.05). Conclusion: If the clinical symptoms may not be obvious, the detection of Bcl-2 and Bax proteins level by immunohistochemistry still could be ancillary method.

Original language	English
Pages (from-to)	246-248+253
Journal	Fa yi xue za zhi
Volume	25
Issue number	4
DOIs	https://doi.org/10.3969/j.issn.1004-5619.2009.04.002
State	Published - Aug 2009
Externally published	Yes

Keywords

Bax protein
Bcl-2 protein
Cardiac
Forensic toxicology
Macleaya cordata
Myocytes
Poisoning
Rats

Access to Document

10.3969/j.issn.1004-5619.2009.04.002

Cite this

@article{e75a853dc3a0420d8e6223edaa9d539b,

title = "Expression of Bcl-2 and Bax proteins in myocardial cells after Macleaya cordata alkaloids poisoning in rats",

abstract = "Objective: To observe the expression of Bcl-2 and Bax proteins in rat's myocardial cells after Macleaya cordata alkaloids poisoning, and to provide certain molecular biology references for the detection of Macleaya cordata alkaloids poisoning. Methods: Experimental model of Macleaya cordata alkaloids poisoning was established, the expression levels of Bcl-2 and Bax proteins in these cells were detected by immunohistochemistry, and the results were analyzed by computer image system. Results: The expression levels of Bcl-2 and Bax proteins in myocardial cells in poisoning groups were much greater than those in the control groups (P<0.05). Conclusion: If the clinical symptoms may not be obvious, the detection of Bcl-2 and Bax proteins level by immunohistochemistry still could be ancillary method.",

keywords = "Bax protein, Bcl-2 protein, Cardiac, Forensic toxicology, Macleaya cordata, Myocytes, Poisoning, Rats",

author = "Zhang, {De Yu} and Kong, {Qing Quan} and Zhang, {Chun Bing} and Zhu, {Jian Hua} and Chen, {Ming Di} and Peng Wang",

year = "2009",

month = aug,

doi = "10.3969/j.issn.1004-5619.2009.04.002",

language = "English",

volume = "25",

pages = "246--248+253",

journal = "Fa yi xue za zhi",

issn = "1004-5619",

publisher = "Journal of Forensic Medicine",

number = "4",

}

TY - JOUR

T1 - Expression of Bcl-2 and Bax proteins in myocardial cells after Macleaya cordata alkaloids poisoning in rats

AU - Zhang, De Yu

AU - Kong, Qing Quan

AU - Zhang, Chun Bing

AU - Zhu, Jian Hua

AU - Chen, Ming Di

AU - Wang, Peng

PY - 2009/8

Y1 - 2009/8

N2 - Objective: To observe the expression of Bcl-2 and Bax proteins in rat's myocardial cells after Macleaya cordata alkaloids poisoning, and to provide certain molecular biology references for the detection of Macleaya cordata alkaloids poisoning. Methods: Experimental model of Macleaya cordata alkaloids poisoning was established, the expression levels of Bcl-2 and Bax proteins in these cells were detected by immunohistochemistry, and the results were analyzed by computer image system. Results: The expression levels of Bcl-2 and Bax proteins in myocardial cells in poisoning groups were much greater than those in the control groups (P<0.05). Conclusion: If the clinical symptoms may not be obvious, the detection of Bcl-2 and Bax proteins level by immunohistochemistry still could be ancillary method.

AB - Objective: To observe the expression of Bcl-2 and Bax proteins in rat's myocardial cells after Macleaya cordata alkaloids poisoning, and to provide certain molecular biology references for the detection of Macleaya cordata alkaloids poisoning. Methods: Experimental model of Macleaya cordata alkaloids poisoning was established, the expression levels of Bcl-2 and Bax proteins in these cells were detected by immunohistochemistry, and the results were analyzed by computer image system. Results: The expression levels of Bcl-2 and Bax proteins in myocardial cells in poisoning groups were much greater than those in the control groups (P<0.05). Conclusion: If the clinical symptoms may not be obvious, the detection of Bcl-2 and Bax proteins level by immunohistochemistry still could be ancillary method.

KW - Bax protein

KW - Bcl-2 protein

KW - Cardiac

KW - Forensic toxicology

KW - Macleaya cordata

KW - Myocytes

KW - Poisoning

KW - Rats

UR - http://www.scopus.com/inward/record.url?scp=70350145035&partnerID=8YFLogxK

U2 - 10.3969/j.issn.1004-5619.2009.04.002

DO - 10.3969/j.issn.1004-5619.2009.04.002

M3 - Article

C2 - 19788070

AN - SCOPUS:70350145035

SN - 1004-5619

VL - 25

SP - 246-248+253

JO - Fa yi xue za zhi

JF - Fa yi xue za zhi

IS - 4

ER -

Expression of Bcl-2 and Bax proteins in myocardial cells after Macleaya cordata alkaloids poisoning in rats

Abstract

Keywords

Access to Document

Fingerprint

Cite this