Abstract
Objective: To investigate the expression pattern of WNT1, beta-catenin and TCF4 in basal cell carcinoma(BCC). Methods: The expression pattern of WNT1, beta-catenin and TCF4 was determined using immunohistocheinical staining, Western blot and real-Time quantitative I'CR in 62 BCC and 56 seborrheic keratosis (SK). Results: The positive expression rates of WNT1, beta-catenin and TCF4 in basal cell carcinoma were significantly higher than that in SK [WNT1: 87.10%(54/ 62) vs. 25%( 14/56); beta-catenin: 83.87%(52/62) vs. 19.64%( 11/56); TCF4: 93.55%(58/62) vs. 10.71%(6/56); /'<0.000 1 for all]. The expression levels of mRNA and protein for WNT1, beta-catenin and TCF4 in BCC were significantly higher than that in SK(/'<0.05 for all). Conclusion: The abnormal expression pattern of WNT1, beta-catenin and TCF4 is associated with the development of BCC.
Original language | English |
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Pages (from-to) | 503-506 |
Number of pages | 4 |
Journal | Journal of Clinical Dermatology |
Volume | 45 |
Issue number | 7 |
DOIs | |
State | Published - 5 Jul 2016 |
Externally published | Yes |
Keywords
- Basal cell carcinoma
- Beta-catenin
- Elderly
- TCF4
- WNT1