Expression and significance of WNT1, beta-catenin, TCF4 in basal cell carcinoma

Sheng Ni Zhang, Tao Zhang, Rui Qi Chu, Chun Mei Liu, Jun Ping Shen, Wen Ying Tian

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To investigate the expression pattern of WNT1, beta-catenin and TCF4 in basal cell carcinoma(BCC). Methods: The expression pattern of WNT1, beta-catenin and TCF4 was determined using immunohistocheinical staining, Western blot and real-Time quantitative I'CR in 62 BCC and 56 seborrheic keratosis (SK). Results: The positive expression rates of WNT1, beta-catenin and TCF4 in basal cell carcinoma were significantly higher than that in SK [WNT1: 87.10%(54/ 62) vs. 25%( 14/56); beta-catenin: 83.87%(52/62) vs. 19.64%( 11/56); TCF4: 93.55%(58/62) vs. 10.71%(6/56); /'<0.000 1 for all]. The expression levels of mRNA and protein for WNT1, beta-catenin and TCF4 in BCC were significantly higher than that in SK(/'<0.05 for all). Conclusion: The abnormal expression pattern of WNT1, beta-catenin and TCF4 is associated with the development of BCC.

Original languageEnglish
Pages (from-to)503-506
Number of pages4
JournalJournal of Clinical Dermatology
Volume45
Issue number7
DOIs
StatePublished - 5 Jul 2016
Externally publishedYes

Keywords

  • Basal cell carcinoma
  • Beta-catenin
  • Elderly
  • TCF4
  • WNT1

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